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Search review questions
Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
2 questions in 1 reviews · intervention: Exposure: genetic · outcome domain: Caries increment (DMFS/DMFT)
current versionsNo studies 0 · 0%Ungraded 2 · 100%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Intervention categories, outcome domains and clusters are a proposed key pending human validation. Clear all filters
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
rs10974056 effect allele A (intron variant in GLIS3, chr9:3,889,264) vs Non-effect allele C Dental caries (meta of mixed phenotypes: present-study self-report + GLIDE clinical DMFS + UKB self-report/dentures) · Adults from Japanese and European cohorts (present-study Japanese direct-to-consumer cohort + GLIDE consortium and UK… · Lifelong (germline genotype), Meta-analysis: present study + GLIDE + UKB Genome-wide association meta-analysis identifies two novel loci associated with dental caries. (2024) | Z-score (meta) -5.494 | 3 studies · 533348 participants | Ungraded |
rs4801882 effect allele G (intron variant in SIGLEC5, chr19:52,127,053) vs Non-effect allele A Dental caries (meta of mixed phenotypes: present-study self-report + GLIDE clinical DMFS + UKB self-report/dentures) · Adults from Japanese and European cohorts (present-study Japanese direct-to-consumer cohort + GLIDE consortium and UK… · Lifelong (germline genotype), Meta-analysis: present study + GLIDE + UKB Genome-wide association meta-analysis identifies two novel loci associated with dental caries. (2024) | Z-score (meta) -5.639 | 3 studies · 533348 participants | Ungraded |