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Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
371 questions in 6 reviews · intervention: Exposure: genetic · outcome domain: Caries (unspecified)
current versionsNo studies 0 · 0%Ungraded 371 · 100%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Intervention categories, outcome domains and clusters are a proposed key pending human validation. Clear all filters
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
TT genotype of AMELX rs17878486 vs CC genotype of AMELX rs17878486 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Ethnicity: Asian Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 0.93 [0.04, 23.52] | 1 study | Ungraded |
CT genotype of AMELX rs946252 vs CC genotype of AMELX rs946252 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Age group: Children Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.24 [0.61, 2.49] | 2 studies | Ungraded |
AG + GG genotype (G-allele carriers) of LTF rs1126478 vs AA genotype of LTF rs1126478 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Control group: Caries-free Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 0.99 [0.81, 1.23] | 4 studies | Ungraded |
GG genotype of LTF rs1126478 vs AA + AG genotype of LTF rs1126478 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Overall Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 0.95 [0.80, 1.13] | 4 studies · 2662 participants | Ungraded |
T allele of AMELX rs6639060 vs C allele of AMELX rs6639060 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Overall Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.08 [0.63, 1.85] | 2 studies · 301 participants | Ungraded |
TT genotype of AMELX rs2106416 vs CC + CT genotype of AMELX rs2106416 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Age group: Children Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.67 [0.44, 6.34] | 3 studies | Ungraded |
GG genotype of LTF rs1126478 vs AA genotype of LTF rs1126478 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Ethnicity: Caucasian Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.49 [0.58, 3.85] | 2 studies | Ungraded |
CT genotype of AMELX rs6639060 vs CC genotype of AMELX rs6639060 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Overall Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.27 [0.49, 3.30] | 2 studies · 301 participants | Ungraded |
AMELX rs2106416 CT + TT genotype vs CC genotype Dental caries susceptibility · Individuals with caries/high caries and caries-free or low-caries controls · Overall (n=3) Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 0.59 [0.15, 2.31] | 3 studies · 285 participants | Ungraded |
GG genotype of ENAM rs1264848 vs AA + AG genotype of ENAM rs1264848 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Age group: Children Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 0.66 [0.37, 1.17] | 4 studies | Ungraded |
CT + TT genotype (T-allele carriers) of AMELX rs17878486 vs CC genotype of AMELX rs17878486 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Ethnicity: Caucasian Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 2.03 [0.10, 42.44] | 2 studies | Ungraded |
TT genotype of AMELX rs2106416 vs CC + CT genotype of AMELX rs2106416 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Overall Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.67 [0.44, 6.34] | 3 studies · 285 participants | Ungraded |
TT genotype of ENAM rs3796703 vs CC + CT genotype of ENAM rs3796703 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Age group: Children Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 2.90 [0.92, 9.12] | 2 studies | Ungraded |
G allele of ENAM rs3796704 vs A allele of ENAM rs3796704 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Age group: Children Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.46 [0.92, 2.32] | 2 studies | Ungraded |
GG genotype of ENAM rs1264848 vs AA + AG genotype of ENAM rs1264848 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Ethnicity: Caucasian Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 0.76 [0.34, 1.72] | 4 studies | Ungraded |
AG + GG genotype (G-allele carriers) of ENAM rs1264848 vs AA genotype of ENAM rs1264848 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Overall Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.24 [0.93, 1.67] | 5 studies · 1534 participants | Ungraded |
AG genotype of ENAM rs1264848 vs AA genotype of ENAM rs1264848 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Age group: Children Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.30 [0.84, 2.01] | 4 studies | Ungraded |
LTF rs1126478 AG genotype vs AA genotype Dental caries susceptibility · Individuals with caries/high caries and caries-free or low-caries controls · Overall (n=4) Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.00 [0.80, 1.25] | 4 studies · 2662 participants | Ungraded |
LTF rs2073495 variant vs Reference allele/genotype Dental caries · Human subjects with dental caries and caries-free controls · Single study (Doetzer et al. 2015) The association between genetic variants in lactotransferrin and dental caries: a meta- and gene-based… (2020) | OR 0.99 [0.86, 1.15] | 1 study · 677 participants | Ungraded |
G allele of ENAM rs1264848 vs A allele of ENAM rs1264848 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Ethnicity: Mixed Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.23 [0.79, 1.91] | 1 study | Ungraded |
CT + TT genotype (T-allele carriers) of AMELX rs946252 vs CC genotype of AMELX rs946252 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Control group: Low caries Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 0.98 [0.46, 2.07] | 1 study | Ungraded |