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Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
371 questions in 6 reviews · intervention: Exposure: genetic · outcome domain: Caries (unspecified)
current versionsNo studies 0 · 0%Ungraded 371 · 100%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Intervention categories, outcome domains and clusters are a proposed key pending human validation. Clear all filters
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
AMELX rs17878486 TT genotype vs CC genotype Dental caries susceptibility · Ethnicity: Caucasian (n=2) individuals with caries/high caries and controls · Ethnicity: Caucasian (n=2) Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 5.12 [0.09, 278.85] | 2 studies | Ungraded |
AG genotype of ENAM rs3796704 vs AA genotype of ENAM rs3796704 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Control group: Caries-free Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.74 [0.81, 3.74] | 2 studies | Ungraded |
CT + TT genotype (T-allele carriers) of AMELX rs946252 vs CC genotype of AMELX rs946252 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Age group: Children Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.24 [0.66, 2.33] | 2 studies | Ungraded |
AMELX rs2106416 TT genotype vs CC + CT genotype Dental caries susceptibility · Individuals with caries/high caries and caries-free or low-caries controls · Overall (n=3) Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.67 [0.44, 6.34] | 3 studies · 285 participants | Ungraded |
G allele of ENAM rs3796704 vs A allele of ENAM rs3796704 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Control group: Low caries Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 0.97 [0.63, 1.50] | 2 studies | Ungraded |
T allele of AMELX rs17878486 vs C allele of AMELX rs17878486 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Overall Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 2.25 [0.81, 6.24] | 4 studies · 442 participants | Ungraded |
AMELX rs6639060 CT + TT genotype vs CC genotype Dental caries susceptibility · Ethnicity: Caucasian (n=1) individuals with caries/high caries and controls · Ethnicity: Caucasian (n=1) Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.14 [0.56, 2.29] | 1 study | Ungraded |
T allele of AMELX rs17878486 vs C allele of AMELX rs17878486 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Ethnicity: Mixed Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.87 [1.06, 3.30] | 1 study | Ungraded |
AG genotype of ENAM rs3796704 vs AA genotype of ENAM rs3796704 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Ethnicity: Caucasian Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.74 [0.81, 3.74] | 3 studies | Ungraded |
CT + TT genotype (T-allele carriers) of ENAM rs3796703 vs CC genotype of ENAM rs3796703 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Overall Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 0.90 [0.23, 3.63] | 2 studies · 1152 participants | Ungraded |
AMELX rs946252 TT genotype vs CC genotype Dental caries susceptibility · Ethnicity: Mixed (n=1) individuals with caries/high caries and controls · Ethnicity: Mixed (n=1) Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.03 [0.28, 3.75] | 1 study | Ungraded |
AG + GG genotype (G-allele carriers) of ENAM rs1264848 vs AA genotype of ENAM rs1264848 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Ethnicity: Caucasian Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.18 [0.86, 1.62] | 4 studies | Ungraded |
GG genotype of ENAM rs1264848 vs AA genotype of ENAM rs1264848 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Control group: Caries-free Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 0.42 [0.03, 5.41] | 3 studies | Ungraded |
TT genotype of AMELX rs6639060 vs CC + CT genotype of AMELX rs6639060 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Ethnicity: Caucasian Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.00 [0.42, 2.39] | 1 study | Ungraded |
CT genotype of ENAM rs3796703 vs CC genotype of ENAM rs3796703 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Age group: Children Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 0.89 [0.23, 3.48] | 2 studies | Ungraded |
ENAM rs3796703 TT genotype vs CC genotype Dental caries susceptibility · Ethnicity: Asian (n=2) individuals with caries/high caries and controls · Ethnicity: Asian (n=2) Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 5.22 [0.25, 108.96] | 2 studies | Ungraded |
AMELX rs17878486 CT genotype vs CC genotype Dental caries susceptibility · Ethnicity: Caucasian (n=2) individuals with caries/high caries and controls · Ethnicity: Caucasian (n=2) Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.00 [0.12, 8.23] | 2 studies | Ungraded |
CT genotype of AMELX rs17878486 vs CC genotype of AMELX rs17878486 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Ethnicity: Caucasian Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.00 [0.12, 8.23] | 2 studies | Ungraded |
TT genotype of AMELX rs6639060 vs CC + CT genotype of AMELX rs6639060 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Age group: Adults Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.00 [0.42, 2.39] | 1 study | Ungraded |
GG genotype of ENAM rs1264848 vs AA genotype of ENAM rs1264848 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Ethnicity: Caucasian Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 0.67 [0.18, 2.45] | 4 studies | Ungraded |
AMELX rs946252 TT genotype vs CC genotype Dental caries susceptibility · Individuals with caries/high caries and caries-free or low-caries controls · Control group: Low caries (n=1) Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.03 [0.28, 3.75] | 1 study | Ungraded |
CT genotype of AMELX rs17878486 vs CC genotype of AMELX rs17878486 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Overall Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.45 [0.36, 5.80] | 4 studies · 442 participants | Ungraded |
T allele of AMELX rs946252 vs C allele of AMELX rs946252 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Overall Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.01 [0.68, 1.51] | 3 studies · 298 participants | Ungraded |
TT genotype of AMELX rs6639060 vs CC genotype of AMELX rs6639060 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Ethnicity: Caucasian Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.04 [0.43, 2.51] | 1 study | Ungraded |
LTF rs1126478 GG genotype vs AA genotype Dental caries susceptibility · Individuals with caries/high caries and caries-free or low-caries controls · Overall (n=4) Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.03 [0.80, 1.33] | 4 studies · 2662 participants | Ungraded |
CT + TT genotype (T-allele carriers) of ENAM rs3796703 vs CC genotype of ENAM rs3796703 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Age group: Children Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 0.90 [0.23, 3.63] | 2 studies | Ungraded |
G allele of LTF rs1126478 vs A allele of LTF rs1126478 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Age group: Children Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 0.98 [0.87, 1.10] | 4 studies | Ungraded |
T allele of AMELX rs2106416 vs C allele of AMELX rs2106416 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Ethnicity: Caucasian Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.25 [0.77, 2.03] | 2 studies | Ungraded |
T allele of AMELX rs17878486 vs C allele of AMELX rs17878486 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Age group: Children Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 2.48 [0.76, 8.05] | 3 studies | Ungraded |
CT genotype of AMELX rs2106416 vs CC genotype of AMELX rs2106416 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Overall Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 0.55 [0.13, 2.25] | 3 studies · 285 participants | Ungraded |
GG genotype of ENAM rs3796704 vs AA + AG genotype of ENAM rs3796704 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Overall Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.41 [1.06, 1.87] | 4 studies · 1107 participants | Ungraded |
AMELX rs946252 CT genotype vs CC genotype Dental caries susceptibility · Ethnicity: Mixed (n=1) individuals with caries/high caries and controls · Ethnicity: Mixed (n=1) Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 0.95 [0.40, 2.25] | 1 study | Ungraded |
TT genotype of AMELX rs946252 vs CC + CT genotype of AMELX rs946252 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Age group: Children Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.26 [0.56, 2.83] | 2 studies | Ungraded |
CT + TT genotype (T-allele carriers) of AMELX rs946252 vs CC genotype of AMELX rs946252 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Overall Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.21 [0.68, 2.14] | 3 studies · 298 participants | Ungraded |
AMELX rs6639060 TT genotype vs CC + CT genotype Dental caries susceptibility · Ethnicity: Caucasian (n=1) individuals with caries/high caries and controls · Ethnicity: Caucasian (n=1) Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.00 [0.42, 2.39] | 1 study | Ungraded |
CT + TT genotype (T-allele carriers) of AMELX rs2106416 vs CC genotype of AMELX rs2106416 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Ethnicity: Caucasian Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.25 [0.69, 2.27] | 2 studies | Ungraded |
G allele of ENAM rs3796704 vs A allele of ENAM rs3796704 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Overall Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.38 [1.08, 1.76] | 4 studies · 1107 participants | Ungraded |
GG genotype of ENAM rs3796704 vs AA + AG genotype of ENAM rs3796704 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Ethnicity: Caucasian Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.41 [1.04, 1.91] | 3 studies | Ungraded |
CT + TT genotype (T-allele carriers) of AMELX rs946252 vs CC genotype of AMELX rs946252 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Control group: Caries-free Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.63 [0.67, 4.01] | 2 studies | Ungraded |
ENAM rs3796703 TT genotype vs CC + CT genotype Dental caries susceptibility · Ethnicity: Asian (n=2) individuals with caries/high caries and controls · Ethnicity: Asian (n=2) Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 2.90 [0.92, 9.12] | 2 studies | Ungraded |
AG + GG genotype (G-allele carriers) of ENAM rs3796704 vs AA genotype of ENAM rs3796704 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Ethnicity: Caucasian Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 2.16 [1.05, 4.45] | 3 studies | Ungraded |
LTF rs11716497 variant vs Reference allele/genotype Dental caries · Human subjects with dental caries and caries-free controls · Single study (Doetzer et al. 2015) The association between genetic variants in lactotransferrin and dental caries: a meta- and gene-based… (2020) | OR 1.04 [0.90, 1.21] | 1 study · 677 participants | Ungraded |
TT genotype of AMELX rs946252 vs CC + CT genotype of AMELX rs946252 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Overall Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 0.82 [0.43, 1.56] | 3 studies · 298 participants | Ungraded |
LTF rs1126478 AG + GG genotype vs AA genotype Dental caries susceptibility · Individuals with caries/high caries and caries-free or low-caries controls · Overall (n=4) Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 0.99 [0.81, 1.23] | 4 studies · 2662 participants | Ungraded |
AG genotype of LTF rs1126478 vs AA genotype of LTF rs1126478 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Age group: Children Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.00 [0.80, 1.25] | 4 studies | Ungraded |
AG + GG genotype (G-allele carriers) of LTF rs1126478 vs AA genotype of LTF rs1126478 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Overall Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 0.99 [0.81, 1.23] | 4 studies · 2662 participants | Ungraded |
TT genotype of AMELX rs17878486 vs CC genotype of AMELX rs17878486 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Ethnicity: Mixed Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 3.82 [1.19, 12.21] | 1 study | Ungraded |
G allele of LTF rs1126478 vs A allele of LTF rs1126478 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Ethnicity: Caucasian Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.18 [0.66, 2.11] | 2 studies | Ungraded |
CT + TT genotype (T-allele carriers) of AMELX rs6639060 vs CC genotype of AMELX rs6639060 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Age group: Adults Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.14 [0.56, 2.29] | 1 study | Ungraded |
CT + TT genotype (T-allele carriers) of AMELX rs17878486 vs CC genotype of AMELX rs17878486 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Ethnicity: Mixed Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 4.03 [1.27, 12.75] | 1 study | Ungraded |