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Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
4 questions in 3 reviews · intervention: Antimicrobial (other) · outcome domain: Adverse effects/fluorosis
current versionsNo studies 0 · 0%Ungraded 3 · 75%Very low 1 · 25%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Intervention categories, outcome domains and clusters are a proposed key pending human validation. Clear all filters
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Full-mouth scaling (FMS): scaling/root planing (subgingival instrumentation) of all quadrants within 24 hours, without antiseptic vs Quadrant scaling and root planing (control): SRP of each quadrant in separate sessions at least one week apart Adverse events · Adults with a clinical diagnosis of (chronic) periodontitis (1999 classification); studies of aggressive… Full‐mouth treatment modalities (within 24 hours) for periodontitis in adults (2022) · Cochrane | 13 studies provided adverse-event/participant-reported information; 3 reported an event after FMD or FMS; most important harm was increased body temperature after treatment. Narrative, not separated by comparison and… | 13 studies | Ungraded |
Toothbrushing (with or without antiseptics), as part of oral hygiene care vs No toothbrushing (with or without antiseptics) Adverse effects · Critically ill adults receiving mechanical ventilation in ICU Oral hygiene care for critically ill patients to prevent ventilator‐associated pneumonia (2020) · Cochrane | Adverse effects: information from two studies, which stated that there were none; very low certainty. There is a lack of evidence about adverse effects. | 2 studies | Very low |
Povidone iodine rinse vs Saline rinse or placebo Adverse effects · Critically ill patients receiving mechanical ventilation in ICU Oral hygiene care for critically ill patients to prevent ventilator‐associated pneumonia (2020) · Cochrane | Adverse effects (Seguin 2014): no evidence of a difference in acute respiratory distress syndrome (RR 11.00, 95% CI 0.62 to 195.61), agitation and/or hypertension (RR 0.48, 95% CI 0.12 to 1.86), epistaxis (RR 0.14, 95%… | 1 study | Ungraded |
Periodontal treatment (scaling and root planing, polishing, or surgery), alone or with oral hygiene counselling, antiseptics, or antimicrobials vs No treatment Adverse effects of therapy · Pregnant women considered to have periodontal disease (gingivitis or periodontitis) after dental examination Treating periodontal disease for preventing adverse birth outcomes in pregnant women (2017) · Cochrane | 0% in both groups; Not estimated; 2389 participants (4 RCTs) | 4 studies · 2389 participants | Ungraded |