Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,535 questions · 3,601 findings · 252 reviews · Pregnancy and Childbirth

No studies found 726 · 20.2%GRADE not reported 421 · 11.7%Very low 828 · 23%Low 993 · 27.6%Moderate 486 · 13.5%High 147 · 4.1%

Magnesium sulphate vs placebo (outcomes

Death (fetal, neonatal, or later (up to 2 years' corrected age))** · women at risk of preterm birth (< 34 weeks' gestation)

Magnesium sulphate showed no clear difference in death (fetal, neonatal, or later (up to 2 years' corrected age))** compared with placebo (outcomes (moderate certainty).

1 finding from 1 review

Magnesium sulphate vs placebo (outcomes

Death or cerebral palsy · women at risk of preterm birth (< 34 weeks' gestation)

Magnesium sulphate showed no clear difference in death or cerebral palsy (up to school age)** compared with placebo (outcomes (low certainty).

2 findings from 1 review

Magnesium sulphate vs placebo (outcomes

Major neurodevelopmental disability at childhood · women at risk of preterm birth (< 34 weeks' gestation)

It is very uncertain whether magnesium sulphate changes major neurodevelopmental disability (school age)** compared with placebo (outcomes (very low certainty).

1 finding from 1 review

Magnesium sulphate vs placebo (outcomes

Death or major neurodevelopmental disability · women at risk of preterm birth (< 34 weeks' gestation)

Magnesium sulphate showed no clear difference in death or major neurodevelopmental disability (up to school age)** compared with placebo (outcomes (low certainty).

2 findings from 1 review

Magnesium sulphate vs placebo (outcomes

Severe maternal outcome potentially related to treatment (death, respiratory arrest, or cardiac arrest)** · women at risk of preterm birth (< 34 weeks' gestation)

Magnesium sulphate showed no clear difference in severe maternal outcome potentially related to treatment (death,… compared with placebo (outcomes (low certainty).

1 finding from 1 review

Magnesium sulphate vs placebo (outcomes

Cerebral palsy · women at risk of preterm birth (< 34 weeks' gestation)

Magnesium sulphate leads to lower cerebral palsy (up to 2 years' corrected age)** compared with placebo (outcomes (high certainty).

2 findings from 1 review

Magnesium sulphate vs placebo (outcomes

Major disability by 18 to 24 months corrected age (aligned definition) · women at risk of preterm birth (< 34 weeks' gestation)

Magnesium sulphate showed no clear difference in major neurodevelopmental disability (up to 2 years' corrected age)** compared with placebo (outcomes (moderate certainty).

1 finding from 1 review

Magnesium sulphate vs placebo (outcomes

Intraventricular haemorrhage, Papile grade 3/4 · women at risk of preterm birth (< 34 weeks' gestation)

Magnesium sulphate probably leads to lower severe intraventricular haemorrhage (grade 3 or 4) (newborn/infant)** compared with placebo (outcomes (moderate certainty).

1 finding from 1 review

Magnesium sulphate vs placebo (outcomes

Bronchopulmonary dysplasia/chronic lung disease · women at risk of preterm birth (< 34 weeks' gestation)

Magnesium sulphate showed no clear difference in chronic lung disease/bronchopulmonary dysplasia (newborn/infant)** compared with placebo (outcomes (low certainty).

1 finding from 1 review

Magnesium sulphate vs placebo (outcomes

Death (fetal, neonatal, or later (up to school age))** · women at risk of preterm birth (< 34 weeks' gestation)

Magnesium sulphate showed no clear difference in death (fetal, neonatal, or later (up to school age))** compared with placebo (outcomes (low certainty).

1 finding from 1 review

Summary of findings table ‐ Midwife continuity models vs other models of care

Spontaneous vaginal birth · childbearing women and their infants (all) (important/secondary outcomes)

Summary of findings table ‐ Midwife continuity of care models probably leads to higher spontaneous vaginal birth (as defined by trial authors) compared with other models of care (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Midwife continuity models vs other models of care

Induction of labour · childbearing women and their infants (all) (important/secondary outcomes)

Summary of findings table ‐ Midwife continuity models showed no clear difference in induction of labour compared with other models of care (low certainty).

1 finding from 1 review

Summary of findings table ‐ Midwife continuity models vs other models of care

Instrumental vaginal birth · childbearing women and their infants (all) (important/secondary outcomes)

Summary of findings table ‐ Midwife continuity models probably leads to lower instrumental vaginal birth (forceps/vacuum) compared with other models of care (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Midwife continuity models vs other models of care

Episiotomy · childbearing women and their infants (all) (important/secondary outcomes)

Summary of findings table ‐ Midwife continuity models may leads to lower episiotomy compared with other models of care (low certainty).

1 finding from 1 review

Summary of findings table ‐ Midwife continuity models vs other models of care

Third‐ or fourth‐degree perineal tear (with or without episiotomy) · childbearing women and their infants (all) (important/secondary outcomes)

It is very uncertain whether summary of findings table ‐ Midwife continuity models changes third or fourth degree tear compared with other models of care (very low certainty).

1 finding from 1 review