Findings

What do systematic reviews say?

2,119 questions · 2,206 findings · 117 reviews · Common Mental Disorders

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No studies found 387 · 17.5%GRADE not reported 111 · 5%Very low 635 · 28.8%Low 568 · 25.7%Moderate 449 · 20.4%High 56 · 2.5%

Fluoxetine vs venlafaxine

Endpoint score (HDRS or MADRS) · patients with depression

1 finding from 1 review

Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
no estimate extracted
13 studies · 3097 participants
Moderate

Fluoxetine vs venlafaxine

Failure to complete ‐ total ‐ · patients with depression

Fluoxetine showed no clear difference in failure to complete ‐ total ‐ compared with venlafaxine (moderate certainty).

1 finding from 1 review

Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
OR 0.89 [0.74, 1.06]
14 studies · 2683 participants
Moderate

Fluoxetine vs venlafaxine

Failure to complete ‐ inefficacy ‐ · patients with depression

Fluoxetine showed no clear difference in failure to complete ‐ inefficacy ‐ compared with venlafaxine (moderate certainty).

1 finding from 1 review

Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
OR 1.31 [0.91, 1.89]
13 studies · 2640 participants
Moderate

Fluoxetine vs agomelatine

Failure to complete ‐ total ‐ · patients with depression

Fluoxetine showed no clear difference in failure to complete ‐ total ‐ compared with agomelatine (moderate certainty).

1 finding from 1 review

Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
OR 1.31 [0.89, 1.94]
2 studies · 785 participants
Moderate

Fluoxetine vs venlafaxine

Failure to complete ‐ side effects ‐ · patients with depression

Fluoxetine probably leads to lower failure to complete ‐ side effects ‐ compared with venlafaxine (moderate certainty).

1 finding from 1 review

Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
OR 0.72 [0.56, 0.94]
13 studies · 2640 participants
Moderate

Fluoxetine vs agomelatine

Failure to complete ‐ inefficacy ‐ · patients with depression

Fluoxetine showed no clear difference in failure to complete ‐ inefficacy ‐ compared with agomelatine (moderate certainty).

1 finding from 1 review

Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
OR 1.08 [0.41, 2.88]
2 studies · 785 participants
Moderate

Fluoxetine vs agomelatine

Failure to complete ‐ side effects ‐ · patients with depression

Fluoxetine showed no clear difference in failure to complete ‐ side effects ‐ compared with agomelatine (moderate certainty).

1 finding from 1 review

Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
OR 1.51 [0.74, 3.07]
2 studies · 785 participants
Moderate

Fluoxetine vs amineptine

Failure to respond (reduction ≥ 50% on HDRS) · patients with depression

Fluoxetine showed no clear difference in failure to respond (reduction ≥ 50% on HDRS) compared with amineptine (moderate certainty).

1 finding from 1 review

Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
OR 0.37 [0.13, 1.04]
1 study · 63 participants
Moderate

Fluoxetine vs amineptine

Endpoint score (HDRS or MADRS) · patients with depression

1 finding from 1 review

Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Fluoxetine vs amineptine

Failure to complete ‐ total ‐ · patients with depression

Fluoxetine showed no clear difference in failure to complete ‐ total ‐ compared with amineptine (moderate certainty).

1 finding from 1 review

Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
OR 0.61 [0.17, 2.21]
2 studies · 232 participants
Moderate

Fluoxetine vs amineptine

Failure to complete ‐ inefficacy ‐ · patients with depression

Fluoxetine showed no clear difference in failure to complete ‐ inefficacy ‐ compared with amineptine (moderate certainty).

1 finding from 1 review

Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
OR 1.04 [0.19, 5.57]
1 study · 63 participants
Moderate

Fluoxetine vs tricyclic antidepressants (TCAs)

Endpoint score (HDRS or MADRS) · patients with depression

1 finding from 1 review

Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
no estimate extracted
50 studies · 3393 participants
Moderate

Fluoxetine vs amineptine

Failure to complete ‐ side effects ‐ · patients with depression

Fluoxetine showed no clear difference in failure to complete ‐ side effects ‐ (Copy) compared with amineptine (moderate certainty).

1 finding from 1 review

Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
OR 0.52 [0.03, 7.82]
2 studies · 232 participants
Moderate

Fluoxetine vs AMISULPRIDE

Failure to respond (reduction ≥ 50% on HDRS) · patients with depression

1 finding from 1 review

Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Fluoxetine vs AMISULPRIDE

Endpoint score (HDRS or MADRS) · patients with depression

1 finding from 1 review

Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
no estimate extracted
1 study · 268 participants
Low

Fluoxetine vs AMISULPRIDE

Failure to complete ‐ total ‐ · patients with depression

Fluoxetine showed no clear difference in failure to complete ‐ total ‐ compared with amisulpride (low certainty).

1 finding from 1 review

Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
OR 1.39 [0.81, 2.38]
1 study · 281 participants
Low

Fluoxetine vs AMISULPRIDE

Failure to complete ‐ inefficacy ‐ · patients with depression

Fluoxetine showed no clear difference in failure to complete ‐ inefficacy ‐ compared with amisulpride (low certainty).

1 finding from 1 review

Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
OR 1.16 [0.43, 3.1]
1 study · 281 participants
Low

Fluoxetine vs AMISULPRIDE

Failure to complete ‐ side effects ‐ · patients with depression

Fluoxetine showed no clear difference in failure to complete ‐ side effects ‐ compared with amisulpride (low certainty).

1 finding from 1 review

Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
OR 0.77 [0.33, 1.82]
1 study · 281 participants
Low

Fluoxetine vs bupropion

Failure to respond (reduction ≥ 50% on HDRS) · patients with depression

Fluoxetine showed no clear difference in failure to respond (reduction ≥ 50% on HDRS) compared with bupropion (moderate certainty).

1 finding from 1 review

Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
OR 0.83 [0.48, 1.43]
2 studies · 436 participants
Moderate

Fluoxetine vs bupropion

Endpoint score (HDRS or MADRS) · patients with depression

1 finding from 1 review

Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported