Closure of macular hole · participants with idiopathic macular hole
Face‐down positioning or posturing showed no clear difference in macular hole closure (anatomical assessment) compared with no face‐down positioning or posturing after macular hole surgery (low certainty).
1 finding from 1 review
Improved visual acuity (ETDRS chart at 4 metres) · participants with idiopathic macular hole
It is very uncertain whether face‐down positioning or posturing changes improved visual acuity (ETDRS chart at 4 metres) compared with no face‐down positioning or posturing after macular hole surgery (very low certainty).
1 finding from 1 review
Quality of life on a 0 to 100 scale. Various quality of life scales. (higher score is better) · participants with idiopathic macular hole
1 finding from 1 review
Postoperative nerve compression injury (clinical assessment) · participants with idiopathic macular hole
1 finding from 1 review
Progression to visual loss (loss of 3 or more lines on logMAR chart) · proliferative diabetic retinopathy
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Visual acuity · proliferative diabetic retinopathy
1 finding from 1 review
Complete regression of new vessels (dichotomous outcome) · proliferative diabetic retinopathy
Anti‐vascular endothelial growth factor (anti‐VEGF) with or without… probably leads to higher complete regression of new vessels (dichotomous outcome) compared with PRP alone (moderate certainty).
1 finding from 1 review
Regression of new vessels (continuous outcome): mean area of fluorescein leakage (mm2) fluorescein angiography · proliferative diabetic retinopathy
1 finding from 1 review
Presence of vitreous haemorrhaged · proliferative diabetic retinopathy
Anti‐vascular endothelial growth factor (anti‐VEGF) with or without… probably leads to lower presence of vitreous haemorrhaged compared with PRP alone (moderate certainty).
1 finding from 1 review
Need for vitrectomy · proliferative diabetic retinopathy
Anti‐vascular endothelial growth factor (anti‐VEGF) with or without… may leads to lower need for vitrectomy compared with PRP alone (low certainty).
1 finding from 1 review
Quality of life (VFQ‐25 General health) · proliferative diabetic retinopathy
1 finding from 1 review
Adverse events · proliferative diabetic retinopathy
1 finding from 1 review
Change in visual acuity (logMAR) ‐ 12 months (negative is better) · adults with GA due to AMD
1 finding from 1 review
Safety: Development of macular neovascularisation or exudative AMD at 1 year · adults with GA due to AMD
Summary of findings 2: Efficacy and safety of IVT lampalizumab 6‐ to… showed no clear difference in safety: Development of macular neovascularisation or exudative AMD… compared with sham (low certainty).
1 finding from 1 review
Safety: Development of endophthalmitis at 1 year · adults with GA due to AMD
Summary of findings 2: Efficacy and safety of IVT lampalizumab 6‐ to… showed no clear difference in safety: Development of endophthalmitis at 1 year compared with sham (moderate certainty).
1 finding from 1 review
Loss of ≥ 15 letters BCVA at 1 year · adults with GA due to AMD
Summary of findings 2: Efficacy and safety of IVT lampalizumab 6‐ to… showed no clear difference in loss of ≥ 15 letters BCVA at 1 year compared with sham (moderate certainty).
1 finding from 1 review
Change in LLVA from baseline at 1 year (ETDRS letters) · adults with GA due to AMD
1 finding from 1 review
QoL · adults with GA due to AMD
1 finding from 1 review
Change in visual acuity (logMAR) ‐ 12 months (negative is better) · adults with GA due to AMD
1 finding from 1 review
Change in untransformed GA lesion size from baseline at 1 year (mm²) · adults with GA due to AMD
1 finding from 1 review