Findings

What do systematic reviews say?

2,119 questions · 2,206 findings · 117 reviews · Common Mental Disorders

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No studies found 387 · 17.5%GRADE not reported 111 · 5%Very low 635 · 28.8%Low 568 · 25.7%Moderate 449 · 20.4%High 56 · 2.5%

Paroxetine vs hypericum

SMD at endpoint · patients with depression

1 finding from 1 review

Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
no estimate extracted
1 study · 244 participants
Moderate

Paroxetine vs hypericum

Failure to complete ‐ any cause ‐ · patients with depression

Paroxetine showed no clear difference in failure to complete ‐ any cause ‐ compared with hypericum (moderate certainty).

1 finding from 1 review

Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
OR 1.9 [0.98, 3.67]
1 study · 251 participants
Moderate

Paroxetine vs hypericum

Participants with at least some Side Effects · patients with depression

Paroxetine probably leads to higher participants with at least some Side Effects compared with hypericum (moderate certainty).

1 finding from 1 review

Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
OR 2.6 [1.51, 4.46]
1 study · 251 participants
Moderate

Paroxetine vs milnacipran

Failure to respond at endpoint (6‐12 weeks) · patients with depression

Paroxetine showed no clear difference in failure to respond at endpoint (6‐12 weeks) compared with milnacipran (moderate certainty).

1 finding from 1 review

Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
OR 0.93 [0.59, 1.47]
1 study · 302 participants
Moderate

Paroxetine vs milnacipran

Failure to respond at 1‐4 weeks · patients with depression

1 finding from 1 review

Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Paroxetine vs agomelatine

Failure to respond at endpoint (6‐12 weeks) · patients with depression

Paroxetine showed no clear difference in failure to respond at endpoint (6‐12 weeks) compared with agomelatine (moderate certainty).

1 finding from 1 review

Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
OR 1.25 [0.78, 2.01]
1 study · 284 participants
Moderate

Paroxetine vs milnacipran

Failure to respond at 16‐24 weeks · patients with depression

1 finding from 1 review

Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Paroxetine vs milnacipran

Failure to remit at endpoint · patients with depression

Paroxetine showed no clear difference in failure to remit at endpoint compared with milnacipran (moderate certainty).

1 finding from 1 review

Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
OR 0.92 [0.57, 1.49]
1 study · 302 participants
Moderate

Paroxetine vs milnacipran

SMD at endpoint · patients with depression

1 finding from 1 review

Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
no estimate extracted
1 study · 299 participants
Moderate

Paroxetine vs milnacipran

Failure to complete ‐ any cause ‐ · patients with depression

Paroxetine showed no clear difference in failure to complete ‐ any cause ‐ compared with milnacipran (moderate certainty).

1 finding from 1 review

Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
OR 1.17 [0.67, 2.3]
2 studies · 343 participants
Moderate

Paroxetine vs milnacipran

Participants with at least some Side Effects · patients with depression

Paroxetine showed no clear difference in participants with at least some Side Effects compared with milnacipran (moderate certainty).

1 finding from 1 review

Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
OR 0.69 [0.41, 1.15]
1 study · 302 participants
Moderate

Paroxetine vs mirtazapine

Failure to respond at endpoint (6‐12 weeks) · patients with depression

Paroxetine showed no clear difference in failure to respond at endpoint (6‐12 weeks) compared with mirtazapine (moderate certainty).

1 finding from 1 review

Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
OR 1.2 [0.9, 1.61]
4 studies · 766 participants
Moderate

Paroxetine vs mirtazapine

Failure to respond at 1‐4 weeks · patients with depression

Paroxetine probably leads to higher failure to respond at 1‐4 weeks compared with mirtazapine (moderate certainty).

1 finding from 1 review

Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
OR 2.39 [1.42, 4.02]
3 studies · 726 participants
Moderate

Paroxetine vs mirtazapine

Failure to respond at 16‐24 weeks · patients with depression

Paroxetine showed no clear difference in failure to respond at 16‐24 weeks compared with mirtazapine (moderate certainty).

1 finding from 1 review

Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
OR 1.41 [0.81, 2.48]
3 studies · 726 participants
Moderate

Paroxetine vs mirtazapine

Failure to remit at endpoint · patients with depression

Paroxetine probably leads to higher failure to remit at endpoint compared with mirtazapine (moderate certainty).

1 finding from 1 review

Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
OR 1.52 [1.13, 2.06]
4 studies · 766 participants
Moderate

Paroxetine vs mirtazapine

SMD at endpoint · patients with depression

1 finding from 1 review

Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
no estimate extracted
1 study · 246 participants
Moderate

Paroxetine vs agomelatine

Failure to respond at 1‐4 weeks · patients with depression

1 finding from 1 review

Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Paroxetine vs mirtazapine

Failure to complete ‐ any cause ‐ · patients with depression

Paroxetine showed no clear difference in failure to complete ‐ any cause ‐ compared with mirtazapine (moderate certainty).

1 finding from 1 review

Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
OR 1.26 [0.91, 1.74]
3 studies · 726 participants
Moderate

Paroxetine vs mirtazapine

Participants with at least some Side Effects · patients with depression

Paroxetine showed no clear difference in participants with at least some Side Effects compared with mirtazapine (moderate certainty).

1 finding from 1 review

Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
OR 1.07 [0.76, 1.5]
3 studies · 726 participants
Moderate

Paroxetine vs nefazodone

Failure to respond at endpoint (6‐12 weeks) · patients with depression

Paroxetine showed no clear difference in failure to respond at endpoint (6‐12 weeks) compared with nefazodone (moderate certainty).

1 finding from 1 review

Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
OR 0.31 [0.07, 1.25]
1 study · 40 participants
Moderate