Findings

What do systematic reviews say?

2,234 questions · 2,325 findings · 216 reviews · Airways

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No studies found 249 · 10.7%GRADE not reported 107 · 4.6%Very low 276 · 11.9%Low 751 · 32.3%Moderate 718 · 30.9%High 224 · 9.6%

Erdosteine vs no treatment

Hospitalisations for infective exacerbations · people with bronchiectasis

The review found no eligible studies for this question.

1 finding from 1 review

Mucolytics for bronchiectasis 2014 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Erdosteine vs no treatment

Adverse events · people with bronchiectasis

The review found no eligible studies for this question.

1 finding from 1 review

Mucolytics for bronchiectasis 2014 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Erdosteine vs no treatment

Health‐related quality of life · people with bronchiectasis

The review found no eligible studies for this question.

1 finding from 1 review

Mucolytics for bronchiectasis 2014 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Erdosteine vs no treatment

Symptoms mucus volume production · people with bronchiectasis

Erdosteine showed no clear difference in symptoms mucus volume production compared with no treatment (low certainty).

1 finding from 1 review

Mucolytics for bronchiectasis 2014 · Cochrane Headline outcomes only
MD 0.4
1 study · 30 participants
Low

Bromhexine vs placebo

Hospital admissions · people with bronchiectasis

The review found no eligible studies for this question.

1 finding from 1 review

Mucolytics for bronchiectasis 2014 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Erdosteine vs no treatment

Deaths · people with bronchiectasis

The review found no eligible studies for this question.

1 finding from 1 review

Mucolytics for bronchiectasis 2014 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Erdosteine vs no treatment

FEV1 · people with bronchiectasis

Erdosteine may leads to higher lung function change in FEV1 (L) at day 15 compared with no treatment (low certainty).

1 finding from 1 review

Mucolytics for bronchiectasis 2014 · Cochrane Headline outcomes only
MD 200 [40, 360]
1 study · 30 participants
Low

Bromhexine vs placebo

Adverse events · people with bronchiectasis

Bromhexine showed no clear difference in adverse events compared with placebo (low certainty).

1 finding from 1 review

Mucolytics for bronchiectasis 2014 · Cochrane Headline outcomes only
OR 2.93 [0.12, 73.97]
1 study · 88 participants
Low

Bromhexine vs placebo

Health‐related quality of life · people with bronchiectasis

The review found no eligible studies for this question.

1 finding from 1 review

Mucolytics for bronchiectasis 2014 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Bromhexine vs placebo

Symptoms difficulty in expectoration · people with bronchiectasis

Bromhexine showed no clear difference in symptoms difficulty in expectoration compared with placebo (low certainty).

1 finding from 1 review

Mucolytics for bronchiectasis 2014 · Cochrane Headline outcomes only
no estimate extracted
1 study · 88 participants
Low

Bromhexine vs placebo

Deaths · people with bronchiectasis

The review found no eligible studies for this question.

1 finding from 1 review

Mucolytics for bronchiectasis 2014 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Bromhexine vs placebo

Lung function (FEV₁) · people with bronchiectasis

Bromhexine showed no clear difference in lung function FEV1 compared with placebo (low certainty).

1 finding from 1 review

Mucolytics for bronchiectasis 2014 · Cochrane Headline outcomes only
MD 184
1 study · 88 participants
Low

RhDNase vs placebo

Frequency and duration of exacerbations · people with bronchiectasis

The review found no eligible studies for this question.

1 finding from 1 review

Mucolytics for bronchiectasis 2014 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

RhDNase vs placebo

Hospitalisations for infective exacerbations · people with bronchiectasis

RhDNase showed no clear difference in hospitalisations for infective exacerbations compared with placebo (low certainty).

1 finding from 1 review

Mucolytics for bronchiectasis 2014 · Cochrane Headline outcomes only
OR 5.54 [0.25, 123.08]
1 study · 40 participants
Low

Summary of findings ‐ Inhaled mannitol vs placebo

Annual Exacerbation Rates · people with bronchiectasis

Inhaled mannitol showed no clear difference in exacerbations Exacerbation rate per year. compared with placebo (moderate certainty).

1 finding from 1 review

Inhaled hyperosmolar agents for bronchiectasis 2014 · Cochrane Headline outcomes only
RR 0.92 [0.78, 1.08]
1 study · 461 participants
Moderate

Hypertonic saline vs Normal saline

Adverse events · people with bronchiectasis

Hypertonic saline showed no clear difference in adverse events compared with isotonic saline; GRADE not reported.

1 finding from 1 review

Inhaled hyperosmolar agents for bronchiectasis 2014 · Cochrane Headline outcomes only
OR 8.2 [0.4, 169.9]
1 study · 40 participants
GRADE not reported

Hypertonic saline vs Normal saline

All‐cause mortality · people with bronchiectasis

1 finding from 1 review

Inhaled hyperosmolar agents for bronchiectasis 2014 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 113 participants
GRADE not reported

Hypertonic saline vs Normal saline

Symptoms: cough, sputum volume and ease of expectoration, wheeze, dyspnoea · people with bronchiectasis

1 finding from 1 review

Inhaled hyperosmolar agents for bronchiectasis 2014 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 113 participants
GRADE not reported

Hypertonic saline vs Normal saline

FEV1 (L) · people with bronchiectasis

1 finding from 1 review

Inhaled hyperosmolar agents for bronchiectasis 2014 · Cochrane Headline outcomes only
no estimate extracted
1 study · 40 participants
Moderate

Hypertonic saline vs Normal saline

SGRQ Total SGRQ (Total) Score. Scale from: 0 to 100. Lower score indicates better quality of life. · people with bronchiectasis

1 finding from 1 review

Inhaled hyperosmolar agents for bronchiectasis 2014 · Cochrane Headline outcomes only
no estimate extracted
1 study · 40 participants
Moderate