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What do systematic reviews say?

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Evidence found and GRADE certainty

4,811 questions · 70,850 findings · 5,139 reviews

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No studies found 15,174 · 21.4%GRADE not reported 6,479 · 9.1%Very low 17,330 · 24.5%Low 17,814 · 25.1%Moderate 11,056 · 15.6%High 2,997 · 4.2%

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Omega‐3 vs placebo

Adverse effects (any adverse effect) · sickle cell disease

It is very uncertain whether omega‐3 changes adverse effects (any adverse effect) compared with placebo (very low certainty).

1 finding from 1 review

Vitamin C 1400 mg plus vitamin E 800 mg vs placebo

Acute chest syndrome ( · adults with sickle cell disease (adults with homozygous SCA or sickle beta 0 thalassaemia SCD)

It is very uncertain whether vitamin C 1400 mg plus vitamin E 800 mg changes frequency of sickle cell‐related complications: acute chest syndrome compared with placebo (very low certainty).

1 finding from 1 review

Zinc vs placebo

Frequency of crisis · people with sickle cell disease

Zinc showed no clear difference in frequency of crisis compared with placebo (low certainty).

1 finding from 1 review