Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,494 questions · 1,521 findings · 132 reviews · Hepato-Biliary

No studies found 303 · 19.9%GRADE not reported 39 · 2.6%Very low 876 · 57.6%Low 216 · 14.2%Moderate 65 · 4.3%High 22 · 1.4%

Summary of findings table ‐ Rifaximin vs placebo or no intervention

Serious adverse events ‐ total number of participants · prevention and treatment of hepatic encephalopathy in people with cirrhosis

Summary of findings table ‐ Rifaximin showed no clear difference in serious adverse events ‐ total number of participants compared with placebo/no intervention (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Rifaximin vs placebo or no intervention

Hepatic encephalopathy · prevention and treatment of hepatic encephalopathy in people with cirrhosis

Summary of findings table ‐ Rifaximin probably leads to lower hepatic encephalopathy ‐ total number compared with placebo/no intervention (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Rifaximin vs placebo or no intervention

Non‐serious adverse events ‐ total number of particiapnts · prevention and treatment of hepatic encephalopathy in people with cirrhosis

It is very uncertain whether summary of findings table ‐ Rifaximin changes non‐serious adverse events ‐ total number of particiapnts compared with placebo/no intervention (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Rifaximin vs non‐absorbable disaccharide

Mortality ‐ total number · prevention and treatment of hepatic encephalopathy in people with cirrhosis

Summary of findings table ‐ Rifaximin showed no clear difference in mortality ‐ total number compared with non‐absorbable disaccharide (low certainty).

1 finding from 1 review

Summary of findings table ‐ Rifaximin vs non‐absorbable disaccharide

Serious adverse events ‐ total number of participants · prevention and treatment of hepatic encephalopathy in people with cirrhosis

Summary of findings table ‐ Rifaximin showed no clear difference in serious adverse events ‐ total number of participants compared with non‐absorbable disaccharide (low certainty).

1 finding from 1 review

ePTFE‐covered stents vs bare stents

Hepatic encephalopathy · transjugular intrahepatic portosystemic shunt in people with liver cirrhosis

It is very uncertain whether ePTFE‐covered stents changes hepatic encephalopathy compared with bare stents (very low certainty).

2 findings from 1 review

ePTFE‐covered stents vs bare stents

Upper gastrointestinal bleeding · transjugular intrahepatic portosystemic shunt in people with liver cirrhosis

ePTFE‐covered stents may leads to lower upper gastrointestinal bleeding compared with bare stents (low certainty).

2 findings from 1 review

ePTFE‐covered stents vs bare stents

Recurrence of ascites · transjugular intrahepatic portosystemic shunt in people with liver cirrhosis

ePTFE‐covered stents may leads to lower recurrence of ascites compared with bare stents (low certainty).

2 findings from 1 review

ePTFE‐covered stents vs bare stents

Total mortalitya · transjugular intrahepatic portosystemic shunt in people with liver cirrhosis

It is very uncertain whether ePTFE‐covered stents changes all‐cause mortalitya compared with bare stents (very low certainty).

1 finding from 1 review

ePTFE‐covered stents vs bare stents

Procedure‐related complications · transjugular intrahepatic portosystemic shunt in people with liver cirrhosis

It is very uncertain whether ePTFE‐covered stents changes procedure‐related complications compared with bare stents (very low certainty).

1 finding from 1 review

Exercise vs control

All‐cause mortality at end of intervention (range 2–10 months) · adult patients after liver transplantation.

It is very uncertain whether exercise changes all‐cause mortality at end of intervention (range 2–10 months) compared with control (very low certainty).

1 finding from 1 review