Children: higher dose/longer course vs lower dose/shorter course
Re‐admission during · children with acute asthma
1 finding from 1 review
- no estimate extracted1 study · 98 participantsVery low
Findings
What do systematic reviews say?
2,234 questions · 2,325 findings · 216 reviews · Airways
No studies found 249 · 10.7%GRADE not reported 107 · 4.6%Very low 276 · 11.9%Low 751 · 32.3%Moderate 718 · 30.9%High 224 · 9.6%
Children: higher dose/longer course vs lower dose/shorter course
Asthma symptoms · children with acute asthma
Children: higher dose/longer course showed no clear difference in asthma symptoms Symptom free by 7 days compared with lower dose/shorter course (moderate certainty).
1 finding from 1 review
- OR 1.22 [0.67, 2.19]1 study · 201 participantsModerate
Children: higher dose/longer course vs lower dose/shorter course
Serious adverse events · children with acute asthma
1 finding from 1 review
- no estimate extracted1 study · 201 participantsGRADE not reported
Children: higher dose/longer course vs lower dose/shorter course
Exacerbations · children with acute asthma
Children: higher dose/longer course showed no clear difference in new exacerbation during compared with lower dose/shorter course (low certainty).
2 findings from 1 review
- OR 1.38 [0.25, 7.47]2 studies · 231 participantsLow
- OR 2.17 [0.67, 7.01]1 study · 100 participantsVery low
Children: higher dose/longer course vs lower dose/shorter course
FEV1 % predicted · children with acute asthma
1 finding from 1 review
- no estimate extracted1 study · 34 participantsGRADE not reported
Children: higher dose/longer course vs lower dose/shorter course
All adverse events · children with acute asthma
Children: higher dose/longer course showed no clear difference in all adverse events compared with lower dose/shorter course (moderate certainty).
1 finding from 1 review
- OR 0.67 [0.11, 4.08]1 study · 201 participantsModerate
Children: prednisolone vs dexamethasone
Admission to hospital at initial presentation · children with acute asthma
Children: prednisolone showed no clear difference in admission at initial presentation compared with dexamethasone (low certainty).
1 finding from 1 review
- OR 1.08 [0.74, 1.58]3 studies · 1007 participantsLow
Adults: higher dose/longer course vs lower dose/shorter course
Asthma severity and symptoms · Adults with acute asthma
1 finding from 1 review
- no estimate extracted1 study · 44 participantsLow
Children: prednisolone vs dexamethasone
Re‐admission during · children with acute asthma
Children: prednisolone showed no clear difference in re‐admission during compared with dexamethasone (low certainty).
1 finding from 1 review
- OR 0.44 [0.15, 1.33]3 studies · 985 participantsLow
Children: prednisolone vs dexamethasone
Asthma symptoms · children with acute asthma
2 findings from 1 review
- no estimate extracted2 studies · 328 participantsVery low
- no estimate extracted1 study · 533 participantsGRADE not reported
Children: prednisolone vs dexamethasone
Serious adverse events · children with acute asthma
1 finding from 1 review
- no estimate extracted2 studies · 255 participantsGRADE not reported
Children: prednisolone vs dexamethasone
Exacerbations · children with acute asthma
Children: prednisolone showed no clear difference in new exacerbation during compared with dexamethasone (low certainty).
1 finding from 1 review
- OR 0.85 [0.54, 1.34]4 studies · 981 participantsLow
Adults: higher dose/longer course vs lower dose/shorter course
Asthma symptoms Complete resolution by day 28 · Adults with acute asthma
Adults: higher dose/longer course showed no clear difference in asthma symptoms Complete resolution by day 28 compared with lower dose/shorter course (low certainty).
1 finding from 1 review
- OR 0.55 [0.13, 2.26]1 study · 35 participantsLow
Adults: higher dose/longer course vs lower dose/shorter course
Exacerbations · Adults with acute asthma
It is very uncertain whether adults: higher dose/longer course changes new exacerbation in compared with lower dose/shorter course (very low certainty).
2 findings from 1 review
- OR 0.98 [0.17, 5.56]2 studies · 55 participantsVery low
- OR 0.62 [0.23, 1.68]3 studies · 122 participantsLow
Adults: higher dose/longer course vs lower dose/shorter course
FEV1 % predicted · Adults with acute asthma
1 finding from 1 review
- no estimate extracted2 studies · 41 participantsVery low
Adults: higher dose/longer course vs lower dose/shorter course
All adverse events · Adults with acute asthma
It is very uncertain whether adults: higher dose/longer course changes all adverse events compared with lower dose/shorter course (very low certainty).
1 finding from 1 review
- OR 4.15 [0.94, 18.41]1 study · 43 participantsVery low
Adults: prednisolone vs dexamethasone
Re‐admission during · Adults with acute asthma
It is very uncertain whether adults: prednisolone changes re‐admission during compared with dexamethasone (very low certainty).
1 finding from 1 review
- OR 0.35 [0.04, 3.47]1 study · 200 participantsVery low
Adults: prednisolone vs dexamethasone
Asthma symptoms Returned to normal activities within 3 days · Adults with acute asthma
Adults: prednisolone showed no clear difference in asthma symptoms Returned to normal activities within 3 days compared with dexamethasone (low certainty).
1 finding from 1 review
- OR 0.44 [0.19, 1.01]1 study · 191 participantsLow
CBT vs usual care
Health‐related quality of life (AQLQ)Scale from: 1‐7 (higher is better) · adults and adolescents with asthma
1 finding from 1 review
- Cognitive behavioural therapy (CBT) for adults and adolescents with asthma 2016 · Cochrane Headline outcomes onlyno estimate extracted6 studies · 214 participantsLow
CBT vs usual care
Mean exacerbations requiring a course of oral corticosteroids · adults and adolescents with asthma
The review found no eligible studies for this question.
1 finding from 1 review
- Cognitive behavioural therapy (CBT) for adults and adolescents with asthma 2016 · Cochrane Headline outcomes onlyno estimate extractedStudies not reportedNo studies found