Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,923 questions · 1,956 findings · 143 reviews · Musculoskeletal

No studies found 555 · 28.4%GRADE not reported 107 · 5.5%Very low 255 · 13%Low 555 · 28.4%Moderate 357 · 18.3%High 127 · 6.5%

Intervention not reported

Remission Achievement of disease activity score < 2.6 · participants with rheumatoid arthritis and with a partial response to DMARDs

The intervention leads to higher remission Achievement of disease activity score < 2.6 (high certainty).

1 finding from 1 review

Intervention not reported

Etanercept + DMARD vs. DMARD · participants with rheumatoid arthritis

The intervention leads to higher etanercept + DMARD vs. DMARD (high certainty).

1 finding from 1 review

Intervention not reported

Etanercept vs. DMARD · participants with rheumatoid arthritis

The intervention leads to higher etanercept vs. DMARD (high certainty).

1 finding from 1 review

Intervention not reported

Etanercept + DMARD vs. Etanercept · participants with rheumatoid arthritis

The intervention probably leads to higher etanercept + DMARD vs. Etanercept (moderate certainty).

1 finding from 1 review

Intervention not reported

Etanercept (25 mg) + DMARD · participants with rheumatoid arthritis
1 finding from 1 review

Intervention not reported

Reduction in disability score Health Assessment Questionnaire. Scale from: 0 to 3 · participants with rheumatoid arthritis and with a partial response to DMARDs
1 finding from 1 review

Intervention not reported

Radiographic progression Total Sharp Score Scale from: 0 to 448 · participants with rheumatoid arthritis and with a partial response to DMARDs
1 finding from 1 review

Intervention not reported

Withdrawals due to adverse events · participants with rheumatoid arthritis and with a partial response to DMARDs

The intervention showed no clear difference in withdrawals due to adverse events (moderate certainty).

1 finding from 1 review

Intervention not reported

Serious adverse events · participants with rheumatoid arthritis and with a partial response to DMARDs

The intervention showed no clear difference in serious adverse events (moderate certainty).

1 finding from 1 review

Intervention not reported

Serious infections · participants with rheumatoid arthritis and with a partial response to DMARDs

The intervention showed no clear difference in serious infections (high certainty).

1 finding from 1 review

Intervention not reported

ACR50 American College of Rheumatology improvement criteria · participants with rheumatoid arthritis and with partial response to MTX

The intervention probably leads to higher ACR50 American College of Rheumatology improvement criteria (moderate certainty).

1 finding from 1 review

Intervention not reported

Remission Disease activity score < 2.6 · participants with rheumatoid arthritis and with partial response to MTX
1 finding from 1 review

Posterior cruciate ligament retention vs sacrifice (all types of arthroplasty designs)

Performance based measures ‐ Range of motion (possible range 0 (worst) to 140 (maximal) degrees) · Patients receiving total knee arthroplasty with or without posterior stabilised design for the treatment of osteoarthritis
1 finding from 1 review

Posterior cruciate ligament retention vs sacrifice (using the same arthroplasty design)

Survival rate of the implant (Revision surgery reported) · Patients receiving total knee arthroplasty with or without resection of the posterior cruciate ligament for the treatment of osteoarthritis

The review found no eligible studies for this question.

1 finding from 1 review

Posterior cruciate ligament retention vs sacrifice (using the same arthroplasty design)

Health related quality of life measures and functional measures with validated instruments (WOMAC, range 0‐100, higher scores indicate worse pain, stiffness and functional limitations) · Patients receiving total knee arthroplasty with or without resection of the posterior cruciate ligament for the treatment of osteoarthritis

The review found no eligible studies for this question.

1 finding from 1 review

Posterior cruciate ligament retention vs sacrifice (using the same arthroplasty design)

Global assessment (patient) Patient satisfaction on scale 0 (not at all satisfied) to 10 (completely satisfied) · Patients receiving total knee arthroplasty with or without resection of the posterior cruciate ligament for the treatment of osteoarthritis
1 finding from 1 review

Posterior cruciate ligament retention vs sacrifice (using the same arthroplasty design)

Complications · Patients receiving total knee arthroplasty with or without resection of the posterior cruciate ligament for the treatment of osteoarthritis

The review found no eligible studies for this question.

1 finding from 1 review

Posterior cruciate ligament retention vs sacrifice (using the same arthroplasty design)

Re‐operation rate (not involving implant change, short and long term) · Patients receiving total knee arthroplasty with or without resection of the posterior cruciate ligament for the treatment of osteoarthritis

The review found no eligible studies for this question.

1 finding from 1 review