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Evidence found and GRADE certainty

2,293 questions · 2,395 findings · 172 reviews · Gut

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No studies found 420 · 17.5%GRADE not reported 60 · 2.5%Very low 821 · 34.3%Low 602 · 25.1%Moderate 397 · 16.6%High 95 · 4%

Summary of findings table (subcomparison 4): targeted therapy agent plus control intervention vs control intervention

Progression‐free survival · palliative participants with esophageal and GE‐junction carcinoma

Summary of findings table (subcomparison 4): targeted therapy agent… probably leads to lower progression‐free survival compared with control intervention alone (moderate certainty).

1 finding from 1 review

Summary of findings table (subcomparison 4): targeted therapy agent plus control intervention vs control intervention

Toxicity · palliative participants with esophageal and GE‐junction carcinoma

It is very uncertain whether summary of findings table (subcomparison 4): targeted therapy agent… changes toxicity compared with control intervention alone (very low certainty).

1 finding from 1 review

Summary of findings table (subcomparison 5): chemotherapy or targeted therapy agent(s) plus control intervention vs control intervention

Overall survival · palliative participants with AC of the esophagus

Summary of findings table (subcomparison 5): chemotherapy or… leads to lower overall survival compared with control intervention alone (high certainty).

1 finding from 1 review

Summary of findings table (subcomparison 5): chemotherapy or targeted therapy agent(s) plus control intervention vs control intervention

Progression‐free survival · palliative participants with AC of the esophagus

It is very uncertain whether summary of findings table (subcomparison 5): chemotherapy or… changes progression‐free survival compared with control intervention alone (very low certainty).

1 finding from 1 review

Summary of findings table (subcomparison 5): chemotherapy or targeted therapy agent(s) plus control intervention vs control intervention

Toxicity · palliative participants with AC of the esophagus

It is very uncertain whether summary of findings table (subcomparison 5): chemotherapy or… changes toxicity compared with control intervention alone (very low certainty).

1 finding from 1 review

Summary of findings table (subcomparison 5): chemotherapy or targeted therapy agent(s) plus control intervention vs control intervention

Toxicity · palliative participants with esophageal and GE‐junction carcinoma

It is very uncertain whether summary of findings table: chemotherapy or targeted therapy agent(s)… changes toxicity compared with control intervention alone (very low certainty).

1 finding from 1 review

Summary of findings table (subcomparison 5): chemotherapy or targeted therapy agent(s) plus control intervention vs control intervention

Overall survival · palliative participants with SCC of the esophagus

Summary of findings table (subcomparison 6): chemotherapy or… leads to lower overall survival compared with control intervention alone (high certainty).

1 finding from 1 review

Summary of findings table (subcomparison 5): chemotherapy or targeted therapy agent(s) plus control intervention vs control intervention

Progression‐free survival · palliative participants with SCC of the esophagus

It is very uncertain whether summary of findings table (subcomparison 6): chemotherapy or… changes progression‐free survival compared with control intervention alone (very low certainty).

1 finding from 1 review

Summary of findings table (subcomparison 5): chemotherapy or targeted therapy agent(s) plus control intervention vs control intervention

Toxicity · palliative participants with SCC of the esophagus

It is very uncertain whether summary of findings table (subcomparison 6): chemotherapy or… changes toxicity compared with control intervention alone (very low certainty).

1 finding from 1 review

Summary of findings table (sensitivity analysis): interventions esophageal and GE‐junction carcinoma vs gastric carcinoma

Studies with gastric cancer participants in addition to eligible participants · palliative participants with esophageal and GE‐junction carcinoma or gastric carcinoma

Summary of findings table (sensitivity analysis): interventions… showed no clear difference in studies with gastric cancer participants in addition to eligible… compared with gastric carcinoma; GRADE not reported.

1 finding from 1 review

Summary of findings table (sensitivity analysis): interventions esophageal and GE‐junction carcinoma vs gastric carcinoma

Sensitivity analysis, meta‐regression analysis, first part · palliative participants with esophageal and GE‐junction carcinoma or gastric carcinoma

It is very uncertain whether summary of findings table (sensitivity analysis): interventions… changes sensitivity analysis, meta‐regression analysis, first part compared with gastric carcinoma (very low certainty).

1 finding from 1 review

Summary of findings table (sensitivity analysis): interventions esophageal and GE‐junction carcinoma vs gastric carcinoma

Sensitivity analysis, only esophageal and GE‐junction cancer participants · palliative participants with esophageal and GE‐junction carcinoma or gastric carcinoma

Summary of findings table (sensitivity analysis): interventions… led to lower sensitivity analysis, only esophageal and GE‐junction cancer… compared with gastric carcinoma; GRADE not reported.

1 finding from 1 review

Summary of findings table (sensitivity analysis): interventions esophageal and GE‐junction carcinoma vs gastric carcinoma

Sensitivity analysis, only gastric cancer participants · palliative participants with esophageal and GE‐junction carcinoma or gastric carcinoma

Summary of findings table (sensitivity analysis): interventions… showed no clear difference in sensitivity analysis, only gastric cancer participants compared with gastric carcinoma; GRADE not reported.

1 finding from 1 review

Summary of findings table (sensitivity analysis): interventions esophageal and GE‐junction carcinoma vs gastric carcinoma

Sensitivity analysis, meta‐regression analysis, second part · palliative participants with esophageal and GE‐junction carcinoma or gastric carcinoma

Summary of findings table (sensitivity analysis): interventions… probably leads to lower sensitivity analysis, meta‐regression analysis, second part compared with gastric carcinoma (moderate certainty).

1 finding from 1 review