Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,494 questions · 1,521 findings · 132 reviews · Hepato-Biliary

No studies found 303 · 19.9%GRADE not reported 39 · 2.6%Very low 876 · 57.6%Low 216 · 14.2%Moderate 65 · 4.3%High 22 · 1.4%

Intervention not reported

All‐cause mortality low risk of bias Mortality · patients with preventing hepatitis A.

The intervention showed no clear difference in all‐cause mortality low risk of bias Mortality (high certainty).

1 finding from 1 review

Intervention not reported

All‐cause mortality all included trials Mortality · patients with preventing hepatitis A.

The intervention showed no clear difference in all‐cause mortality all included trials Mortality (high certainty).

1 finding from 1 review

Intervention not reported

Clinically apparent hepatitis A (inactivated HAV vaccines) low risk of bias trials Dienstag 1999 · patients with preventing hepatitis A.

The intervention leads to lower clinically apparent hepatitis A (inactivated HAV vaccines) low risk… (high certainty).

1 finding from 1 review

Intervention not reported

Lack of sero‐protection, (anti HAV IgG < 10mIU/L) (low risk of bias) Maiwald 1997 · patients with preventing hepatitis A.

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Lack of sero‐protection, (anti HAV IgG < 10mIU/L) (all included trials) Maiwald 1997 · patients with preventing hepatitis A.

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Lack of sero‐protection, (anti HAV IgG < 20mIU/L) (low risk of bias ) Maiwald 1997 · patients with preventing hepatitis A.

The intervention leads to lower lack of sero‐protection, (anti HAV IgG < 20mIU/L) (low risk of bias… (high certainty).

1 finding from 1 review

Intervention not reported

Lack of sero‐protection, (anti HAV IgG < 20mIU/L) (all included trials) Maiwald 1997 · patients with preventing hepatitis A.

The intervention may leads to lower lack of sero‐protection, (anti HAV IgG < 20mIU/L) (all included… (low certainty).

1 finding from 1 review

Intervention not reported

Non‐serious local adverse events (low risk of bias) inactivated HAV vaccine ICH‐GCP 1997 · patients with preventing hepatitis A.

The intervention showed no clear difference in non‐serious local adverse events (low risk of bias) inactivated HAV… (high certainty).

1 finding from 1 review

Intervention not reported

Non‐serious local adverse events (all included trials) ICH‐GCP 1997 · patients with preventing hepatitis A.

The intervention showed no clear difference in non‐serious local adverse events (all included trials) ICH‐GCP 1997 (low certainty).

1 finding from 1 review

Intervention not reported

Non‐serious systemic adverse events (low risk of bias) inactivated HAV vaccine ICH‐GCP 1997 · patients with preventing hepatitis A.

The intervention showed no clear difference in non‐serious systemic adverse events (low risk of bias) inactivated… (high certainty).

1 finding from 1 review

Intervention not reported

Non‐serious systemic adverse events (all included studies) inactivated HAV vaccine ICH‐GCP 1997 · patients with preventing hepatitis A.

The intervention showed no clear difference in non‐serious systemic adverse events (all included studies)… (low certainty).

1 finding from 1 review

Intervention not reported

Non‐serious local adverse events (low risk of bias) live attenuated HAV vaccine ICH‐GCP 1997 · patients with preventing hepatitis A.

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Non‐serious local adverse events (all included studies) live attenuated HAV vaccine ICH‐GCP 1997 · patients with preventing hepatitis A.

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Clinically apparent hepatitis A (inactivated HAV vaccines) all included trials Dienstag 1999 · patients with preventing hepatitis A.

The intervention may leads to lower clinically apparent hepatitis A (inactivated HAV vaccines) all… (low certainty).

1 finding from 1 review

Intervention not reported

Non‐serious systemic adverse events (low risk of bias) live attenuated HAV vaccine ICH‐GCP 1997 · patients with preventing hepatitis A.

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Non‐serious systemic adverse events (all included studies) live attenuated HAV vaccine ICH‐GCP 1997 · patients with preventing hepatitis A.

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Clinically apparent hepatitis A (live attenuated HAV vaccines) low risk of bias Dienstag 1999 · patients with preventing hepatitis A.

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Clinically apparent hepatitis A (live attenuated HAV vaccines) all included trials Dienstag 1999 · patients with preventing hepatitis A.

It is very uncertain whether the intervention changes clinically apparent hepatitis A (live attenuated HAV vaccines) all… (very low certainty).

1 finding from 1 review

Intervention not reported

Clinically apparent hepatitis A (Dose of live attenuated HAV vaccine, titre >= TCID50 ) low risk of bias Dienstag 1999 · patients with preventing hepatitis A.

The review found no eligible studies for this question.

1 finding from 1 review