Mesalamine vs placebo
Clinical response · Patients with collagenous colitis
Mesalamine showed no clear difference in clinical response compared with placebo (low certainty).
1 finding from 1 review
- RR 0.74 [0.44, 1.24]1 study · 62 participantsLow
Findings
What do systematic reviews say?
2,293 questions · 2,395 findings · 172 reviews · Gut
No studies found 420 · 17.5%GRADE not reported 60 · 2.5%Very low 821 · 34.3%Low 602 · 25.1%Moderate 397 · 16.6%High 95 · 4%
Mesalamine vs placebo
Histological response · Patients with collagenous colitis
Mesalamine showed no clear difference in histological response compared with placebo (low certainty).
1 finding from 1 review
- RR 0.86 [0.5, 1.47]1 study · 62 participantsLow
Mesalamine vs placebo
Adverse events · Patients with collagenous colitis
Mesalamine showed no clear difference in adverse events compared with placebo (low certainty).
1 finding from 1 review
- RR 1.26 [0.84, 1.88]1 study · 62 participantsLow
Mesalamine vs placebo
Withdrawals due to adverse events · Patients with collagenous colitis
Mesalamine showed no clear difference in withdrawals due to adverse events compared with placebo (low certainty).
1 finding from 1 review
- RR 5.92 [0.7, 49.9]1 study · 62 participantsLow
Mesalamine vs placebo
Serious adverse events · Patients with collagenous colitis
Mesalamine showed no clear difference in serious adverse events compared with placebo (low certainty).
1 finding from 1 review
- RR 4.44 [0.49, 40.29]1 study · 62 participantsLow
Mesalazine vs mesalazine + cholestyramine
Clinical response · Patients with collagenous colitis
It is very uncertain whether mesalazine changes clinical response compared with mesalazine + cholestyramine (very low certainty).
1 finding from 1 review
- RR 0.74 [0.5, 1.08]1 study · 23 participantsVery low
Mesalazine vs mesalazine + cholestyramine
Adverse events · Patients with collagenous colitis
It is very uncertain whether mesalazine changes adverse events compared with mesalazine + cholestyramine (very low certainty).
1 finding from 1 review
- RR 0.22 [0.01, 4.07]1 study · 23 participantsVery low
Adults: prednisolone vs placebo
Clinical response · Patients with collagenous colitis
It is very uncertain whether prednisolone changes clinical response compared with placebo (very low certainty).
1 finding from 1 review
- RR 4.89 [0.35, 68.83]1 study · 11 participantsVery low
Probiotics vs placebo
Clinical response · Patients with collagenous colitis
It is very uncertain whether probiotics changes clinical response compared with placebo (very low certainty).
1 finding from 1 review
- RR 2.29 [0.32, 16.13]1 study · 29 participantsVery low
Bismuth subsalicylate vs placebo
Histological response · Patients with collagenous colitis
It is very uncertain whether bismuth subsalicylate changes histological response compared with placebo (very low certainty).
1 finding from 1 review
- RR 10.8 [0.75, 155.93]1 study · 9 participantsVery low
Probiotics vs placebo
Adverse events · Patients with collagenous colitis
It is very uncertain whether probiotics changes adverse events compared with placebo (very low certainty).
1 finding from 1 review
- RR 0.57 [0.22, 1.5]1 study · 29 participantsVery low
Budesonide vs placebo
Clinical response sensitivity analysis excluding Miehlke 2014 · Patients with collagenous colitis
Budesonide may leads to higher clinical response sensitivity analysis excluding Miehlke 2014 compared with placebo (low certainty).
1 finding from 1 review
- RR 4.56 [2.43, 8.55]3 studies · 94 participantsLow
Budesonide vs placebo
Histological response sensitivity analysis excluding Miehlke 2014 · Patients with collagenous colitis
Budesonide may leads to higher histological response sensitivity analysis excluding Miehlke 2014 compared with placebo (low certainty).
1 finding from 1 review
- RR 4.15 [2.25, 7.66]3 studies · 94 participantsLow
Budesonide vs placebo
Maintenance of clinical response · Patients with collagenous colitis
Budesonide may leads to higher maintenance of clinical response compared with placebo (low certainty).
1 finding from 1 review
- RR 3.3 [2.13, 5.09]3 studies · 172 participantsLow
Budesonide vs placebo
Maintenance of histological response · Patients with collagenous colitis
It is very uncertain whether budesonide changes maintenance of histological response compared with placebo (very low certainty).
1 finding from 1 review
- RR 3.17 [1.44, 6.95]2 studies · 80 participantsVery low
Budesonide vs placebo
Adverse events · Patients with collagenous colitis
Budesonide showed no clear difference in adverse events compared with placebo (low certainty).
1 finding from 1 review
- RR 1.18 [0.92, 1.51]5 studies · 290 participantsLow
Budesonide vs placebo
Withdrawals due to adverse events · Patients with collagenous colitis
It is very uncertain whether budesonide changes withdrawals due to adverse events compared with placebo (very low certainty).
1 finding from 1 review
- RR 0.97 [0.43, 2.17]5 studies · 290 participantsVery low
Budesonide vs placebo
Serious adverse events · Patients with collagenous colitis
It is very uncertain whether budesonide changes serious adverse events compared with placebo (very low certainty).
1 finding from 1 review
- RR 1.11 [0.15, 8.01]4 studies · 175 participantsVery low
Boswellia serrata vs placebo
Clinical response · Patients with collagenous colitis
Boswellia serrata extract showed no clear difference in clinical response compared with placebo (low certainty).
1 finding from 1 review
- RR 1.64 [0.6, 4.49]1 study · 31 participantsLow
Boswellia serrata vs placebo
Adverse events · Patients with collagenous colitis
Boswellia serrata extract showed no clear difference in adverse events compared with placebo (low certainty).
1 finding from 1 review
- RR 1.88 [0.19, 18.6]1 study · 31 participantsLow