Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,495 questions · 1,554 findings · 140 reviews · Heart

No studies found 272 · 17.5%GRADE not reported 44 · 2.8%Very low 329 · 21.2%Low 464 · 29.9%Moderate 319 · 20.5%High 126 · 8.1%

Intervention not reported

Positive serology: RCT data ‐ nitroderivatives Conventional serology, AT and F29 ELISA techniques · people with chronic asymptomatic Trypanosoma cruzi infection

The intervention probably leads to lower positive serology: RCT data ‐ nitroderivatives Conventional… (moderate certainty).

1 finding from 1 review

Intervention not reported

Positive PCR: RCT data ‐ benznidazole‐ Children PCR · people with chronic asymptomatic Trypanosoma cruzi infection

The intervention showed no clear difference in positive PCR: RCT data ‐ benznidazole‐ Children PCR (moderate certainty).

1 finding from 1 review

Intervention not reported

Positive xenodiagnosis: all populations ‐ RCT data ‐ nitroderivatives Xenodiagnosis · people with chronic asymptomatic Trypanosoma cruzi infection

The intervention leads to lower positive xenodiagnosis: all populations ‐ RCT data ‐… (high certainty).

1 finding from 1 review

Intervention not reported

Mean reduction of antibodies titres: all populations, all tested drugs Mean change of antibodies · people with chronic asymptomatic Trypanosoma cruzi infection
1 finding from 1 review

Intervention not reported

ECG Abnormalities ‐ RCT data ‐ benznidazole · people with chronic asymptomatic Trypanosoma cruzi infection

The intervention showed no clear difference in ECG Abnormalities ‐ RCT data ‐ benznidazole (low certainty).

1 finding from 1 review

Intervention not reported

Progression of cardiomyopathy: non‐RCT data ‐ adults ‐ nitroderivatives Emergence of substantial changes in the diagnostic tests or clinical status, or both (see text) · people with chronic asymptomatic Trypanosoma cruzi infection

It is very uncertain whether the intervention changes progression of cardiomyopathy: non‐RCT data ‐ adults ‐… (very low certainty).

1 finding from 1 review

Intervention not reported

Mortality: non‐RCT data ‐ adults ‐ nitroderivatives All‐cause mortality · people with chronic asymptomatic Trypanosoma cruzi infection

It is very uncertain whether the intervention changes mortality: non‐RCT data ‐ adults ‐ nitroderivatives All‐cause… (very low certainty).

1 finding from 1 review

Shengmai vs placebo

Lack of improvement in heart failure ( NYHA class improved < I class or worsening of heart failure) · patients with heart failure

Shengmai may leads to lower lack of improvement in heart failure (NYHA class improved < I class… compared with placebo (low certainty).

1 finding from 1 review