Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,495 questions · 1,554 findings · 140 reviews · Heart

No studies found 272 · 17.5%GRADE not reported 44 · 2.8%Very low 329 · 21.2%Low 464 · 29.9%Moderate 319 · 20.5%High 126 · 8.1%

Fibrates vs control

Stroke, myocardial infarction, or vascular death · People with previous clinical manifestations of cardiovascular disease, transient ischaemic attack, or stroke

Fibrates probably leads to lower composite outcome of non‐fatal stroke, non‐fatal myocardial… compared with control (moderate certainty).

1 finding from 1 review

Fibrates vs control

Fatal or nonfatal stroke · People with previous clinical manifestations of cardiovascular disease, transient ischaemic attack, or stroke

Fibrates showed no clear difference in stroke (ischaemic or haemorrhagic, non‐fatal or fatal) during the… compared with control (low certainty).

2 findings from 1 review

Fibrates vs control

Death from any cause during the treatment and scheduled · People with previous clinical manifestations of cardiovascular disease, transient ischaemic attack, or stroke

Fibrates showed no clear difference in death from any cause during the treatment and scheduled compared with control (low certainty).

2 findings from 1 review

Fibrates vs control

Deaths due to vascular events · People with previous clinical manifestations of cardiovascular disease, transient ischaemic attack, or stroke

Fibrates showed no clear difference in death from vascular causes during the treatment and scheduled compared with control (low certainty).

2 findings from 1 review

Fibrates vs control

Fatal or nonfatal myocardial infarction · People with previous clinical manifestations of cardiovascular disease, transient ischaemic attack, or stroke

Fibrates probably leads to lower myocardial infarction (non‐fatal or fatal) during the treatment and… compared with control (moderate certainty).

2 findings from 1 review

Fibrates vs control

Composite outcome of non‐fatal stroke, non‐fatal myocardial infarction, and vascular death without clofibrate · People with previous clinical manifestations of cardiovascular disease, transient ischaemic attack, or stroke

Fibrates showed no clear difference in composite outcome of non‐fatal stroke, non‐fatal myocardial… compared with control (low certainty).

1 finding from 1 review

Nurse‐led titration vs usual care

Heart failure hospitalisation (RR) · people with heart failure with reduced ejection fraction

Nurse‐led titration probably leads to lower heart failure‐related hospital admissions compared with usual care (moderate certainty).

1 finding from 1 review

Nurse‐led titration vs usual care

Proportion reaching target dose of medications · people with heart failure with reduced ejection fraction

Nurse‐led titration may leads to higher proportion reaching target dose of medications compared with usual care (low certainty).

1 finding from 1 review