Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,079 questions · 2,112 findings · 171 reviews · Eyes and Vision

No studies found 587 · 27.8%GRADE not reported 95 · 4.5%Very low 446 · 21.1%Low 557 · 26.4%Moderate 361 · 17.1%High 66 · 3.1%

Laser photocoagulation vs no intervention

Worsening of BCVA defined as ≥ 15 ETDRS letters (i.e. 3 ETDRS lines or 0.3 logMAR · people with diabetic macular oedema

Laser photocoagulation probably leads to lower worsening of BCVA defined as ≥ 15 ETDRS letters (i.e. 3 ETDRS lines… compared with no intervention (moderate certainty).

1 finding from 1 review

Laser photocoagulation vs no intervention

Anatomic measures: partial to complete resolution of the macular oedema with stereoscopic fundus photography or biomicroscopy; leakage on fluorescein angiography (IVFA); and, if available, retinal macular thickness with OCT · people with diabetic macular oedema

Laser photocoagulation probably leads to higher anatomic measures: partial to complete resolution of the macular… compared with no intervention (moderate certainty).

1 finding from 1 review

Subthreshold vs standard macular photocoagulation

Improvement of BCVA defined as ≥ 15 ETDRS letters (i.e. 3 ETDRS lines or 0.3 logMAR · people with diabetic macular oedema

It is very uncertain whether subthreshold changes improvement of BCVA defined as ≥ 15 ETDRS letters (i.e. 3 ETDRS… compared with standard macular photocoagulation (very low certainty).

1 finding from 1 review

Subthreshold vs standard macular photocoagulation

Worsening of BCVA defined as ≥ 15 ETDRS letters (i.e. 3 ETDRS lines or 0.3 logMAR · people with diabetic macular oedema

It is very uncertain whether subthreshold changes worsening of BCVA defined as ≥ 15 ETDRS letters (i.e. 3 ETDRS lines… compared with standard macular photocoagulation (very low certainty).

1 finding from 1 review

Intervention not reported

3,4‐DAP (20 mg, single dose) versus placebo. Assessments made 30 minutes after taking the drug or placebo · people with acquired nystagmus
1 finding from 1 review

Intervention not reported

4‐AP (10 mg, single dose) versus 3,4‐DAP (10 mg, single dose) Assessments made at 45 and 90 minutes after taking the drug · people with acquired nystagmus
1 finding from 1 review