Findings

What do systematic reviews say?

2,234 questions · 2,325 findings · 216 reviews · Airways

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No studies found 249 · 10.7%GRADE not reported 107 · 4.6%Very low 276 · 11.9%Low 751 · 32.3%Moderate 718 · 30.9%High 224 · 9.6%

Self‐management interventions vs usual care

Dyspnea · patients with chronic obstructive pulmonary disease

1 finding from 1 review

Self‐management interventions including action plans for exacerbations versus usual care in patients with chronic… 2017 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 217 participants
Low

Self‐management interventions vs usual care

Courses of oral corticosteroids · patients with chronic obstructive pulmonary disease

Self‐management interventions including action plans for exacerbations showed no clear difference in courses of oral steroids compared with usual care (low certainty).

1 finding from 1 review

Self‐management interventions including action plans for exacerbations versus usual care in patients with chronic… 2017 · Cochrane Headline outcomes only
OR 4.38 [0.55, 34.91]
4 studies · 963 participants
Low

Intervention not reported

Cough‐related quality of life (QOL) · people with bronchiectasis

1 finding from 1 review

Positive expiratory pressure therapy versus other airway clearance techniques for bronchiectasis 2017 · Cochrane Headline outcomes only
no estimate extracted
31 participants
Low

Intervention not reported

Health‐related quality of life (HRQOL) disease‐specific HRQOL · people with bronchiectasis

The intervention showed no clear difference in health‐related quality of life (HRQOL) disease‐specific HRQOL (low certainty).

1 finding from 1 review

Positive expiratory pressure therapy versus other airway clearance techniques for bronchiectasis 2017 · Cochrane Headline outcomes only
no estimate extracted
17 participants
Low

Intervention not reported

Incidence of acute exacerbations of bronchiectasis ‐ not reported · people with bronchiectasis

The review found no eligible studies for this question.

1 finding from 1 review

Positive expiratory pressure therapy versus other airway clearance techniques for bronchiectasis 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Duration of acute exacerbation of bronchiectasis ‐ not reported · people with bronchiectasis

The review found no eligible studies for this question.

1 finding from 1 review

Positive expiratory pressure therapy versus other airway clearance techniques for bronchiectasis 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Incidence of hospitalisation ‐ not reported · people with bronchiectasis

The review found no eligible studies for this question.

1 finding from 1 review

Positive expiratory pressure therapy versus other airway clearance techniques for bronchiectasis 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

ICS dose reduction vs no change

Rate of exacerbations requiring systemic corticosteroids · adults with asthma

It is very uncertain whether ICS dose reduction changes exacerbation requiring OCS compared with no change (very low certainty).

2 findings from 1 review

Stepping down the dose of inhaled corticosteroids for adults with asthma 2017 · Cochrane Headline outcomes only
OR 1.86 [0.16, 21.09]
2 studies · 261 participants
Very low
Stepping down the dose of inhaled corticosteroids for adults with asthma 2017 · Cochrane Headline outcomes only
OR 1.31 [0.82, 2.08]
2 studies · 569 participants
Low

ICS dose reduction vs no change

SAEs · adults with asthma

ICS dose reduction showed no clear difference in all‐cause SAEs compared with no change (low certainty).

2 findings from 1 review

Stepping down the dose of inhaled corticosteroids for adults with asthma 2017 · Cochrane Headline outcomes only
OR 0.6 [0.11, 3.33]
2 studies · 569 participants
Low
Stepping down the dose of inhaled corticosteroids for adults with asthma 2017 · Cochrane Headline outcomes only
OR 1.24 [0.25, 6.25]
2 studies · 742 participants
Low

ICS dose reduction vs no change

Steroid‐related AEs ‐ not reported · adults with asthma

The review found no eligible studies for this question.

1 finding from 1 review

Stepping down the dose of inhaled corticosteroids for adults with asthma 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

ICS dose reduction vs no change

St. George's Respiratory Scale score (change from baseline) · adults with asthma

1 finding from 1 review

Stepping down the dose of inhaled corticosteroids for adults with asthma 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 229 participants
Low

ICS dose reduction vs no change

Severe exacerbations requiring hospitalisation over the study period · adults with asthma

ICS dose reduction showed no clear difference in exacerbation requiring hospitalisation compared with no change (low certainty).

1 finding from 1 review

Stepping down the dose of inhaled corticosteroids for adults with asthma 2017 · Cochrane Headline outcomes only
OR 4.06 [0.45, 36.86]
2 studies · 569 participants
Low

ICS dose reduction vs no change

FEV1 · adults with asthma

1 finding from 1 review

Stepping down the dose of inhaled corticosteroids for adults with asthma 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 14 participants
Very low

ICS dose reduction vs no change

Asthma control · adults with asthma

1 finding from 1 review

Stepping down the dose of inhaled corticosteroids for adults with asthma 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 150 participants
Low

ICS dose reduction vs no change

Steroid‐related AEs · adults with asthma

It is very uncertain whether ICS dose reduction changes steroid‐related AEs compared with no change (very low certainty).

1 finding from 1 review

Stepping down the dose of inhaled corticosteroids for adults with asthma 2017 · Cochrane Headline outcomes only
OR 0.76 [0.16, 3.54]
2 studies · 261 participants
Very low

ICS dose reduction vs no change

Change in AQLQ · adults with asthma

1 finding from 1 review

Stepping down the dose of inhaled corticosteroids for adults with asthma 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 554 participants
Very low

ICS dose reduction vs no change

FEV1 (L) · adults with asthma

1 finding from 1 review

Stepping down the dose of inhaled corticosteroids for adults with asthma 2017 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 261 participants
Low

ICS dose reduction vs no change

Exacerbation: hospital 17 weeks · adults with asthma

The review found no eligible studies for this question.

1 finding from 1 review

Stepping down the dose of inhaled corticosteroids for adults with asthma 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

ICS dose reduction vs no change

Asthma control (short asthma morbidity score) · adults with asthma

1 finding from 1 review

Stepping down the dose of inhaled corticosteroids for adults with asthma 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 242 participants
Low

PAAP vs no PAAP

Rate of exacerbations requiring emergency department treatment or admission · adults with asthma

PAAP showed no clear difference in exacerbation requiring ED or hospitalisation. compared with no PAAP (low certainty).

1 finding from 1 review

Personalised asthma action plans for adults with asthma 2017 · Cochrane Headline outcomes only
OR 0.75 [0.45, 1.24]
5 studies · 1385 participants
Low