Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,119 questions · 2,206 findings · 117 reviews · Common Mental Disorders

No studies found 387 · 17.5%GRADE not reported 111 · 5%Very low 635 · 28.8%Low 568 · 25.7%Moderate 449 · 20.4%High 56 · 2.5%

Comparison 1: 5HT1A partial agonists vs placebo

Global Impressions scale change item (CGI‐I or similar): no. of responders (acute phase) · adults with SAnD

It is very uncertain whether comparison 1: 5HT1A partial agonists changes global Impressions scale change item (CGI‐I or similar): no. of… compared with placebo (very low certainty).

1 finding from 1 review

Levetiracetam vs placebo

Withdrawals due to adverse events · adults with SAnD

It is very uncertain whether comparison 3: anticonvulsant levetiracetam changes dropouts due to adverse events (acute phase) compared with placebo (very low certainty).

1 finding from 1 review