ANB · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion)
Surgical miniplates with facemask showed no clear difference in ANB compared with surgical miniplates with Class III elastics; GRADE not reported.
1 finding from 1 review
Time to next/working arch wire · People receiving orthodontic treatment with fixed appliances (upper and/or lower full arch)
The review found no eligible studies for this question.
1 finding from 1 review
Pain · People receiving orthodontic treatment with fixed appliances (upper and/or lower full arch)
The review found no eligible studies for this question.
1 finding from 1 review
Pain: not reported
0 studies
No studies found
Ion release · Human teeth with early enamel lesions surrounding orthodontic brackets
No meta-analysis was conducted; most studies reported increased ion release over time, but few reported peak values.
1 finding from 1 review
no estimate extracted
8 studies
GRADE not reported
ANB · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion)
Facemask with rapid maxillary expansion (RME) led to lower ANB compared with reverse Twin Block with lip pads and rapid maxillary expander (RME); GRADE not reported.
1 finding from 1 review
Perceived need for surgery in adulthood · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion)
The review found no eligible studies for this question.
1 finding from 1 review
White spot lesion incidence · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)
The self-etch primer system had higher WSL incidence than the conventional system, with certainty not graded.
1 finding from 1 review
White spot lesion rate and volume · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)
Opal Seal showed no significant difference in WSL rate or volume, with certainty not graded.
1 finding from 1 review
The WSL volume was lower in the Opal Seal group than in the Clearfil and Transbond XT groups, but there was no significant difference among the groups (p > 0.05).
1 study · 15 participants
GRADE not reported
Enamel demineralization / white spot lesion prevention (DIAGNOdent, enamel mineral content) · Patients undergoing fixed orthodontic (fixed appliance) treatment (adolescents and adults, ages 12 to 35)
Two small RCTs gave inconsistent results for TiO2-modified adhesives/composites on enamel demineralization (one favorable on DIAGNOdent, one no difference in mineral content); ungraded.
1 finding from 1 review
White spot lesions assessed by laser fluorescence (DIAGNOdent) · Patients undergoing fixed orthodontic (fixed appliance) treatment (adolescents and adults, ages 12 to 35)
A single small split-mouth RCT found the nCaF2-containing primer reduced demineralization (DIAGNOdent) but showed no significant clinical white spot lesion difference at debonding (ungraded).
1 finding from 1 review
ANB · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion)
Non-surgical orthodontic treatment (any: facemask, chin cup, tandem… probably leads to higher ANB compared with no treatment (moderate certainty).
1 finding from 1 review
Overjet · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion)
Facemask with rapid maxillary expansion (RME) showed no clear difference in overjet compared with reverse Forsus; GRADE not reported.
1 finding from 1 review
Photographic white spot lesion score · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)
nCaF2 primer showed no clinical photographic WSL difference at debonding, with certainty not graded.
1 finding from 1 review
Enamel remineralization extent and color change · Human enamel specimens around orthodontic brackets (in vitro)
In vitro, an n-AFCP-containing orthodontic primer showed significant enamel remineralization and less color change versus control in a single study (ungraded).
1 finding from 1 review
Time to next/working arch wire · People receiving orthodontic treatment with fixed appliances (upper and/or lower full arch)
The review found no eligible studies for this question.
1 finding from 1 review
Time to next/working arch wire · People receiving orthodontic treatment with fixed appliances (upper and/or lower full arch)
Superelastic NiTi arch wire showed no clear difference in time to next/working arch wire compared with conventional (stabilised) NiTi arch wire; GRADE not reported.
1 finding from 1 review
Intervention not reported
Pathogenic bacteria / plaque composition around brackets (fewer pathogenic bacteria with flash-free vs APC; comparable plaque quantity)
1 finding from 1 review
no estimate extracted
1 study
GRADE not reported
Association between orthodontic treatment duration and ICLs incidence · Patients undergoing fixed orthodontic treatment with fixed (multibracket) appliances, followed for development of new ICLs
ICLs incidence increased with longer orthodontic treatment duration (meta-regression P<.01; ungraded).
1 finding from 1 review
Ion release (fluoride, calcium, phosphate) · Human enamel specimens around orthodontic brackets (in vitro)
In vitro, among the 5 BAG ion-release studies only Ga-doped BAG (GaMBN, Song [31]) reported a significant increase (phosphate, up to 14 days); a general significant fluoride/calcium/phosphate increase across all 5 is not supported (ungraded).
1 finding from 1 review
Streptococcus mutans count · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)
nCaF2 primer differed in S. mutans count only at T1, with certainty not graded.
1 finding from 1 review