Findings

What do systematic reviews say?

4,811 questions · 70,850 findings · 5,139 reviews

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No studies found 15,174 · 21.4%GRADE not reported 6,479 · 9.1%Very low 17,330 · 24.5%Low 17,814 · 25.1%Moderate 11,056 · 15.6%High 2,997 · 4.2%

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Psychosocial interventions vs no intervention

Frequency of drug intake, end of treatment · adults with stimulant use disorder

1 finding from 1 review

Psychosocial interventions for stimulant use disorder 2024 · Cochrane Headline outcomes only
no estimate extracted
9 studies · 1186 participants
High

Psychosocial interventions vs no intervention

Longest period of abstinence · adults with stimulant use disorder

1 finding from 1 review

Psychosocial interventions for stimulant use disorder 2024 · Cochrane Headline outcomes only
no estimate extracted
17 studies · 2118 participants
High

Psychosocial interventions vs treatment

Leaving the study early · adults with stimulant use disorder

Summary of findings table ‐ Any psychosocial intervention leads to lower dropouts compared with treatment (high certainty).

1 finding from 1 review

Psychosocial interventions for stimulant use disorder 2024 · Cochrane Headline outcomes only
RR 0.79 [0.65, 0.97]
9 studies · 735 participants
High

Psychosocial interventions vs treatment

Point abstinence (number of participants who were abstinent at the end of the treatment) · adults with stimulant use disorder

Summary of findings table ‐ Any psychosocial intervention showed no clear difference in point abstinence, end of treatment compared with treatment (low certainty).

1 finding from 1 review

Psychosocial interventions for stimulant use disorder 2024 · Cochrane Headline outcomes only
RR 1.67 [0.64, 4.31]
1 study · 128 participants
Low

Any transvaginal permanent mesh vs native tissue repair

Awareness of prolapse · vaginal prolapse

Transvaginal permanent mesh probably leads to lower awareness of prolapse (0.5 to 7 years) compared with native tissue repair (moderate certainty).

1 finding from 1 review

Transvaginal mesh or grafts or native tissue repair for vaginal prolapse 2024 · Cochrane Headline outcomes only
RR 0.83 [0.73, 0.95]
17 studies · 2932 participants
Moderate

Transvaginal biological graft vs native tissue repair

Surgery for recurrent prolapse · vaginal prolapse

Transvaginal biological graft showed no clear difference in surgery for recurrent prolapse (1 to 2 years) compared with native tissue repair (moderate certainty).

1 finding from 1 review

Transvaginal mesh or grafts or native tissue repair for vaginal prolapse 2024 · Cochrane Headline outcomes only
RR 1.15 [0.75, 1.77]
6 studies · 899 participants
Moderate

Transvaginal biological graft vs native tissue repair

Prolapse on examination ‐ Any recurrent prolapse · vaginal prolapse

Transvaginal biological graft showed no clear difference in recurrent prolapse on examination compared with native tissue repair (low certainty).

1 finding from 1 review

Transvaginal mesh or grafts or native tissue repair for vaginal prolapse 2024 · Cochrane Headline outcomes only
RR 0.96 [0.71, 1.29]
9 studies · 1278 participants
Low

Transvaginal biological graft vs native tissue repair

Visceral injury · vaginal prolapse

Transvaginal biological graft showed no clear difference in visceral injury compared with native tissue repair (low certainty).

1 finding from 1 review

Transvaginal mesh or grafts or native tissue repair for vaginal prolapse 2024 · Cochrane Headline outcomes only
RR 0.34 [0.04, 3.26]
2 studies · 254 participants
Low

Transvaginal biological graft vs native tissue repair

Bladder function · vaginal prolapse

It is very uncertain whether transvaginal biological graft changes bladder function compared with native tissue repair (very low certainty).

1 finding from 1 review

Transvaginal mesh or grafts or native tissue repair for vaginal prolapse 2024 · Cochrane Headline outcomes only
RR 12.64 [1.6, 100.06]
2 studies · 143 participants
Very low

Transvaginal biological graft vs native tissue repair

De novo dyspareunia (pain during sexual intercourse) review 1 to 3 years · vaginal prolapse

Transvaginal biological graft showed no clear difference in painful intercourse ‐ de novo dyspareunia compared with native tissue repair (moderate certainty).

1 finding from 1 review

Transvaginal mesh or grafts or native tissue repair for vaginal prolapse 2024 · Cochrane Headline outcomes only
RR 1.3 [0.46, 3.66]
2 studies · 125 participants
Moderate

Transvaginal biological graft vs native tissue repair

Quality of life · vaginal prolapse

It is very uncertain whether transvaginal biological graft changes quality of life compared with native tissue repair (very low certainty).

1 finding from 1 review

Transvaginal mesh or grafts or native tissue repair for vaginal prolapse 2024 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 112 participants
Very low

Any transvaginal permanent mesh vs native tissue repair

Need for repeat surgery · vaginal prolapse

Transvaginal permanent mesh may leads to higher repeat surgery (0.5 to 7 years) compared with native tissue repair (low certainty).

1 finding from 1 review

Transvaginal mesh or grafts or native tissue repair for vaginal prolapse 2024 · Cochrane Headline outcomes only
RR 1.56 [1.07, 2.26]
27 studies · 3916 participants
Low

Any transvaginal permanent mesh vs native tissue repair

Prolapse on examination ‐ Any recurrent prolapse · vaginal prolapse

It is very uncertain whether transvaginal permanent mesh changes recurrent prolapse on examination (any compartment) compared with native tissue repair (very low certainty).

1 finding from 1 review

Transvaginal mesh or grafts or native tissue repair for vaginal prolapse 2024 · Cochrane Headline outcomes only
RR 0.42 [0.32, 0.55]
25 studies · 3680 participants
Very low

Any transvaginal permanent mesh vs native tissue repair

Visceral injury · vaginal prolapse

Transvaginal permanent mesh may leads to higher visceral injury compared with native tissue repair (low certainty).

1 finding from 1 review

Transvaginal mesh or grafts or native tissue repair for vaginal prolapse 2024 · Cochrane Headline outcomes only
RR 3.67 [1.63, 8.28]
14 studies · 1997 participants
Low

Any transvaginal permanent mesh vs native tissue repair

Mesh exposure · vaginal prolapse

Transvaginal permanent mesh probably leads to higher mesh exposure compared with native tissue repair (moderate certainty).

1 finding from 1 review

Transvaginal mesh or grafts or native tissue repair for vaginal prolapse 2024 · Cochrane Headline outcomes only
RR 11.1 [6.81, 18.1]
26 studies · 2980 participants
Moderate

Any transvaginal permanent mesh vs native tissue repair

Bladder function · vaginal prolapse

Transvaginal permanent mesh probably leads to higher bladder function compared with native tissue repair (moderate certainty).

1 finding from 1 review

Transvaginal mesh or grafts or native tissue repair for vaginal prolapse 2024 · Cochrane Headline outcomes only
RR 1.5 [1.19, 1.88]
17 studies · 2001 participants
Moderate

Any transvaginal permanent mesh vs native tissue repair

De novo dyspareunia (pain during sexual intercourse) review 1 to 3 years · vaginal prolapse

Transvaginal permanent mesh showed no clear difference in painful intercourse ‐ de novo dyspareunia compared with native tissue repair (moderate certainty).

1 finding from 1 review

Transvaginal mesh or grafts or native tissue repair for vaginal prolapse 2024 · Cochrane Headline outcomes only
RR 1.22 [0.83, 1.79]
16 studies · 1308 participants
Moderate

Any transvaginal permanent mesh vs native tissue repair

Quality of life · vaginal prolapse

It is very uncertain whether transvaginal permanent mesh changes quality of life compared with native tissue repair (very low certainty).

1 finding from 1 review

Transvaginal mesh or grafts or native tissue repair for vaginal prolapse 2024 · Cochrane Headline outcomes only
no estimate extracted
9 studies · 1365 participants
Very low

Transvaginal biological graft vs native tissue repair

Awareness of prolapse · vaginal prolapse

Transvaginal biological graft showed no clear difference in awareness of prolapse (1 to 3 years) compared with native tissue repair (moderate certainty).

1 finding from 1 review

Transvaginal mesh or grafts or native tissue repair for vaginal prolapse 2024 · Cochrane Headline outcomes only
RR 1.06 [0.73, 1.56]
8 studies · 1374 participants
Moderate

Metformin vs megestrol

Regression of endometrial hyperplasia (with or without atypia) to proliferative, secretory, or atrophic endometrium · endometrial hyperplasia

It is very uncertain whether summary of findings table ‐ Metformin changes regression of endometrial hyperplasia (with or without atypia) to… compared with megestrol (very low certainty).

1 finding from 1 review

Metformin for endometrial hyperplasia 2024 · Cochrane Headline outcomes only
OR 4.89 [1.56, 15.32]
2 studies · 83 participants
Very low