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Evidence found and GRADE certainty

1,501 questions · 1,558 findings · 115 reviews · Vascular

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No studies found 346 · 22.2%GRADE not reported 90 · 5.8%Very low 281 · 18%Low 477 · 30.6%Moderate 313 · 20.1%High 51 · 3.3%

PGE1 vs inositol niacinate

Ulcer healing · people with critical limb ischaemia

PGE1 showed no clear difference in ulcer healing compared with inositol niacinate (low certainty).

1 finding from 1 review

Iloprost vs PGE1

Cardiovascular mortality · people with critical limb ischaemia

The review found no eligible studies for this question.

1 finding from 1 review

Iloprost vs PGE1

Amputation · people with critical limb ischaemia

Iloprost showed no clear difference in total amputations compared with PGE1 (low certainty).

1 finding from 1 review

Iloprost vs PGE1

Quality of life · people with critical limb ischaemia

The review found no eligible studies for this question.

1 finding from 1 review

Iloprost vs PGE1

Adverse events (participants) · people with critical limb ischaemia

Iloprost probably leads to higher adverse events (participants) compared with PGE1 (moderate certainty).

1 finding from 1 review

Iloprost vs PGE1

Rest‐pain relief · people with critical limb ischaemia

Iloprost showed no clear difference in rest‐pain relief compared with PGE1 (low certainty).

1 finding from 1 review

Iloprost vs PGE1

Ulcer healing · people with critical limb ischaemia

Iloprost showed no clear difference in ulcer healing compared with PGE1 (low certainty).

1 finding from 1 review

Prostanoids vs placebo

Adverse events (participants) · people with critical limb ischaemia

Prostanoids probably leads to higher adverse events (participants) compared with placebo (moderate certainty).

1 finding from 1 review

Clinprost vs lipo‐PGE1

Adverse events · people with critical limb ischaemia

Clinprost showed no clear difference in adverse events compared with lipo‐PGE1 (moderate certainty).

1 finding from 1 review

Clinprost vs lipo‐PGE1

Rest‐pain relief · people with critical limb ischaemia

Clinprost showed no clear difference in rest‐pain relief compared with lipo‐PGE1 (low certainty).

1 finding from 1 review

Clinprost vs lipo‐PGE1

Ulcer healing · people with critical limb ischaemia

Clinprost showed no clear difference in ulcer healing compared with lipo‐PGE1 (low certainty).

1 finding from 1 review

Prostanoids vs placebo

Rest‐pain relief · people with critical limb ischaemia

Prostanoids probably leads to higher rest‐pain relief (dichotomous) compared with placebo (moderate certainty).

1 finding from 1 review

Prostanoids vs placebo

Ulcer healing · people with critical limb ischaemia

Prostanoids probably leads to higher ulcer healing compared with placebo (moderate certainty).

1 finding from 1 review

Prostanoids vs pentoxifylline

Amputation · people with critical limb ischaemia

It is very uncertain whether prostanoids changes total amputations compared with pentoxifylline (very low certainty).

1 finding from 1 review