Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,501 questions · 1,558 findings · 115 reviews · Vascular

No studies found 346 · 22.2%GRADE not reported 90 · 5.8%Very low 281 · 18%Low 477 · 30.6%Moderate 313 · 20.1%High 51 · 3.3%

Prostanoids vs pentoxifylline

Rest‐pain relief · people with critical limb ischaemia

It is very uncertain whether prostanoids changes rest‐pain relief compared with pentoxifylline (very low certainty).

1 finding from 1 review

Prostanoids vs pentoxifylline

Ulcer healing · people with critical limb ischaemia

It is very uncertain whether prostanoids changes ulcer healing compared with pentoxifylline (very low certainty).

1 finding from 1 review

Prostanoids vs naftidrofuryl

Adverse events (participants) · people with critical limb ischaemia

Prostanoids showed no clear difference in adverse events (participants) compared with naftidrofuryl (low certainty).

1 finding from 1 review

Prostanoids vs naftidrofuryl

Rest‐pain relief · people with critical limb ischaemia

Prostanoids showed no clear difference in rest‐pain relief compared with naftidrofuryl (low certainty).

1 finding from 1 review

PGE1 vs ATP

Cardiovascular mortality · people with critical limb ischaemia

The review found no eligible studies for this question.

1 finding from 1 review

Prostanoids vs placebo

Amputation · people with critical limb ischaemia

Prostanoids showed no clear difference in total amputations compared with placebo (high certainty).

1 finding from 1 review

PGE1 vs ATP

Amputation · people with critical limb ischaemia

PGE1 may leads to lower total amputations compared with ATP (low certainty).

1 finding from 1 review

PGE1 vs ATP

Quality of life · people with critical limb ischaemia

The review found no eligible studies for this question.

1 finding from 1 review

PGE1 vs ATP

Adverse event (participants) · people with critical limb ischaemia

PGE1 may leads to higher adverse event (participants) compared with ATP (low certainty).

1 finding from 1 review

PGE1 vs ATP

Ulcer healing (complete) · people with critical limb ischaemia

PGE1 showed no clear difference in ulcer healing (complete) compared with ATP (low certainty).

1 finding from 1 review

PGE1 vs inositol niacinate

Adverse events (participants) · people with critical limb ischaemia

PGE1 showed no clear difference in adverse events (participants) compared with inositol niacinate (low certainty).

1 finding from 1 review

PGE1 vs inositol niacinate

Rest‐pain relief · people with critical limb ischaemia

PGE1 showed no clear difference in rest‐pain relief compared with inositol niacinate (low certainty).

1 finding from 1 review