Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,923 questions · 1,956 findings · 143 reviews · Musculoskeletal

No studies found 555 · 28.4%GRADE not reported 107 · 5.5%Very low 255 · 13%Low 555 · 28.4%Moderate 357 · 18.3%High 127 · 6.5%

Trapeziectomy with ligament reconstruction and tendon interposition (T and LRTI) vs trapeziectomy and ligament reconstruction (T and LR)

Physical function · Patients with thumb (trapeziometacarpal joint) osteoarthritis

Trapeziectomy with ligament reconstruction and tendon interposition… showed no clear difference in physical function Buck‐Gramcko score: Number with good‐excellent… compared with trapeziectomy and ligament reconstruction (T and LR) (low certainty).

1 finding from 1 review

Intervention not reported

Pain intensity Various pain scales. (median · participants with osteoarthritis of the knee

The intervention showed no clear difference in pain intensity Various pain scales. (median (low certainty).

1 finding from 1 review

Intervention not reported

Function Various function scales. (median · participants with osteoarthritis of the knee

The intervention showed no clear difference in function Various function scales. (median (low certainty).

1 finding from 1 review

Intervention not reported

Number of participants experiencing any adverse event (median · participants with osteoarthritis of the knee

The intervention showed no clear difference in number of participants experiencing any adverse event (median (low certainty).

1 finding from 1 review

Intervention not reported

Number of participants who withdraw because of adverse events (median · participants with osteoarthritis of the knee

The intervention showed no clear difference in number of participants who withdraw because of adverse events (median (low certainty).

1 finding from 1 review

Intervention not reported

Number of participants experiencing any serious adverse event (median · participants with osteoarthritis of the knee

The intervention showed no clear difference in number of participants experiencing any serious adverse event (median (low certainty).

1 finding from 1 review

Intervention not reported

ASAS partial remission

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Radiographic progression

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Withdrawals due to adverse events

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Serious adverse events

The review found no eligible studies for this question.

1 finding from 1 review

Chondroitin vs placebo

Pain on a 0 to 100 mm scale ‐ Short‐term studies (< 6 months)—dose ≥ 800 mg/d · patients with osteoarthritis
1 finding from 1 review

Chondroitin vs placebo

Pain on a 0 to 100 scale ‐ Long‐term studies (≥ 6 months)—dose ≥ 800 mg/d · patients with osteoarthritis
1 finding from 1 review