Findings

What do systematic reviews say?

2,252 questions · 2,353 findings · 210 reviews · Neonatal

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No studies found 432 · 18.4%GRADE not reported 99 · 4.2%Very low 609 · 25.9%Low 737 · 31.3%Moderate 385 · 16.4%High 91 · 3.9%

Morphine vs diamorphine

Mortality before hospital discharge · neonates with mechanical ventilation

The review found no eligible studies for this question.

1 finding from 1 review

Opioids for newborn infants receiving mechanical ventilation 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Morphine vs diamorphine

Neurodevelopmental outcomes · neonates with mechanical ventilation

The review found no eligible studies for this question.

3 findings from 1 review

Opioids for newborn infants receiving mechanical ventilation 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found
Opioids for newborn infants receiving mechanical ventilation 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found
Opioids for newborn infants receiving mechanical ventilation 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Fentanyl vs sufentanil

Pain (PIPP) · neonates with mechanical ventilation

The review found no eligible studies for this question.

1 finding from 1 review

Opioids for newborn infants receiving mechanical ventilation 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Opioids vs placebo or no treatment

Neonatal mortality · neonates with mechanical ventilation

Opioids showed no clear difference in neonatal mortality compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Opioids for newborn infants receiving mechanical ventilation 2021 · Cochrane Headline outcomes only
RR 1.12 [0.8, 1.55]
5 studies · 1189 participants
Moderate

Fentanyl vs sufentanil

Duration of mechanical ventilation · neonates with mechanical ventilation

1 finding from 1 review

Opioids for newborn infants receiving mechanical ventilation 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 20 participants
Very low

Fentanyl vs sufentanil

Neonatal mortality · neonates with mechanical ventilation

1 finding from 1 review

Opioids for newborn infants receiving mechanical ventilation 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low

Fentanyl vs sufentanil

Mortality before hospital discharge · neonates with mechanical ventilation

The review found no eligible studies for this question.

1 finding from 1 review

Opioids for newborn infants receiving mechanical ventilation 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Fentanyl vs sufentanil

Neurodevelopmental outcomes · neonates with mechanical ventilation

The review found no eligible studies for this question.

3 findings from 1 review

Opioids for newborn infants receiving mechanical ventilation 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found
Opioids for newborn infants receiving mechanical ventilation 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found
Opioids for newborn infants receiving mechanical ventilation 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Fentanyl vs sufentanil

Not estimable · neonates with mechanical ventilation

Fentanyl showed no clear difference in not estimable compared with sufentanil; GRADE not reported.

1 finding from 1 review

Opioids for newborn infants receiving mechanical ventilation 2021 · Cochrane Headline outcomes only
no estimate extracted
95 participants
GRADE not reported

Fentanyl vs remifentanil

Pain (PIPP) · neonates with mechanical ventilation

The review found no eligible studies for this question.

1 finding from 1 review

Opioids for newborn infants receiving mechanical ventilation 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Fentanyl vs remifentanil

Duration of mechanical ventilation · neonates with mechanical ventilation

The review found no eligible studies for this question.

1 finding from 1 review

Opioids for newborn infants receiving mechanical ventilation 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Fentanyl vs remifentanil

Neonatal mortality · neonates with mechanical ventilation

The review found no eligible studies for this question.

1 finding from 1 review

Opioids for newborn infants receiving mechanical ventilation 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Opioids vs placebo or no treatment

Mortality before hospital discharge · neonates with mechanical ventilation

Opioids showed no clear difference in mortality to discharge compared with placebo or no treatment (low certainty).

1 finding from 1 review

Opioids for newborn infants receiving mechanical ventilation 2021 · Cochrane Headline outcomes only
RR 0.99 [0.52, 1.88]
4 studies · 178 participants
Low

Fentanyl vs remifentanil

Mortality before hospital discharge · neonates with mechanical ventilation

The review found no eligible studies for this question.

1 finding from 1 review

Opioids for newborn infants receiving mechanical ventilation 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Fentanyl vs remifentanil

Neurodevelopmental outcomes · neonates with mechanical ventilation

The review found no eligible studies for this question.

3 findings from 1 review

Opioids for newborn infants receiving mechanical ventilation 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found
Opioids for newborn infants receiving mechanical ventilation 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found
Opioids for newborn infants receiving mechanical ventilation 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Opioids vs placebo or no treatment

Neurodevelopmental outcomes · neonates with mechanical ventilation

It is very uncertain whether opioids changes neurodevelopmental outcomes (18 to 24 months) compared with placebo or no treatment (very low certainty).

3 findings from 1 review

Opioids for newborn infants receiving mechanical ventilation 2021 · Cochrane Headline outcomes only
RR 2 [0.39, 10.29]
1 study · 78 participants
Very low
Opioids for newborn infants receiving mechanical ventilation 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found
Opioids for newborn infants receiving mechanical ventilation 2021 · Cochrane Headline outcomes only
RR 1.6 [0.56, 4.56]
1 study · 95 participants
Very low

Opioids vs other analgesics and sedatives

Pain (PIPP) · neonates with mechanical ventilation

1 finding from 1 review

Opioids for newborn infants receiving mechanical ventilation 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 46 participants
Very low

Opioids vs other analgesics and sedatives

Duration of mechanical ventilation · neonates with mechanical ventilation

1 finding from 1 review

Opioids for newborn infants receiving mechanical ventilation 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 46 participants
Very low

Cefazolin plus amikacin vs vancomycin plus amikacin

All‐cause mortality maximum · newborns with late‐onset sepsis

It is very uncertain whether cefazolin plus amikacin changes all‐cause mortality maximum compared with vancomycin plus amikacin (very low certainty).

1 finding from 1 review

Antibiotic regimens for late‐onset neonatal sepsis 2021 · Cochrane Headline outcomes only
RR 0.7 [0.29, 1.66]
1 study · 109 participants
Very low

Meropenem vs usual care

Serious adverse events maximum · newborns with late‐onset sepsis

It is very uncertain whether meropenem changes serious adverse events maximum compared with standard care (very low certainty).

1 finding from 1 review

Antibiotic regimens for late‐onset neonatal sepsis 2021 · Cochrane Headline outcomes only
RR 1.54 [0.9, 2.66]
1 study · 271 participants
Very low