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What do systematic reviews say?

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Evidence found and GRADE certainty

1,060 questions · 1,105 findings · 84 reviews · Metabolic and Endocrine Disorders

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No studies found 434 · 39.3%GRADE not reported 32 · 2.9%Very low 246 · 22.3%Low 237 · 21.4%Moderate 132 · 11.9%High 24 · 2.2%

Intervention not reported

Costs · postmenopausal women with hypercholesterolaemia

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Death from any cause · participants with hypertriglyceridaemia

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Cardiovascular or cerebrovascular events · participants with hypertriglyceridaemia

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Adverse events [ · participants with hypertriglyceridaemia

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Health‐related quality of life · participants with hypertriglyceridaemia

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Costs · participants with hypertriglyceridaemia

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Serum triglyceride concentrations (mmol/L) [ · participants with hypertriglyceridaemia
1 finding from 1 review

Selenium (+LT4) vs placebo (+LT4)

Change from baseline in assessment of symptoms such as mood, fatigue and muscle weakness Short‐Form Health Survey · participants with Hashimoto's thyroiditis.

Selenium (+LT4) may leads to higher change from baseline in assessment of symptoms such as mood, fatigue… compared with placebo (+LT4) (low certainty).

1 finding from 1 review

Selenium (+LT4) vs placebo (+LT4)

Adverse events post‐intervention Number of people reporting an adverse event before completing the intervention · participants with Hashimoto's thyroiditis.

Selenium (+LT4) showed no clear difference in proportion of participants reporting an adverse event compared with placebo (+LT4) (low certainty).

1 finding from 1 review