Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,234 questions · 2,325 findings · 216 reviews · Airways

No studies found 249 · 10.7%GRADE not reported 107 · 4.6%Very low 276 · 11.9%Low 751 · 32.3%Moderate 718 · 30.9%High 224 · 9.6%

Group 1 Pulmonary arterial hypertension ‐ PDE5i vs placebo, on combination therapy

Improvement in WHO functional class · pulmonary arterial hypertension

Group 1 Pulmonary arterial hypertension ‐ PDE5i showed no clear difference in improvement in WHO functional class compared with placebo, on combination therapy (moderate certainty).

1 finding from 1 review

Prostacyclin vs control

Improvement in WHO functional class · pulmonary arterial hypertension

Prostacyclin probably leads to higher improvement in WHO functional class compared with control (moderate certainty).

1 finding from 1 review