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Evidence found and GRADE certainty

1,060 questions · 1,105 findings · 84 reviews · Metabolic and Endocrine Disorders

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No studies found 434 · 39.3%GRADE not reported 32 · 2.9%Very low 246 · 22.3%Low 237 · 21.4%Moderate 132 · 11.9%High 24 · 2.2%

Intervention not reported

Health‐related quality of life · participants with type 2 diabetes mellitus

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Non‐fatal macrovascular outcomes 1. Composite 2. Non‐fatal myocardial infarction Intervention vs insulin [4.75 years to 10.0 years] · participants with type 2 diabetes mellitus

The intervention showed no clear difference in non‐fatal macrovascular outcomes 1. Composite 2. Non‐fatal… (low certainty).

1 finding from 1 review

Intervention not reported

Cancer Intervention vs insulin [4.75 years to 10.0 years] · participants with type 2 diabetes mellitus

The intervention showed no clear difference in cancer Intervention vs insulin [4.75 years to 10.0 years] (low certainty).

1 finding from 1 review

Intervention not reported

Adverse events 1. All adverse events 2. Drop‐outs due to adverse events Intervention vs alpha‐glucosidase inhibitors [30 weeks] · participants with type 2 diabetes mellitus

The intervention may leads to lower adverse events 1. All adverse events 2. Drop‐outs due to adverse… (low certainty).

1 finding from 1 review

Intervention not reported

Health‐related quality of life · participants with type 2 diabetes mellitus

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

All‐cause mortality a. Intervention vs metformin [a. 24 weeks to 4 years] b. Intervention vs thiazolidinediones [b. 24 weeks to 4 years] c. Intervention vs insulin [c. 9 months to 10 years] d. Intervention vs incretin‐based control [d. 52 weeks to... · participants with type 2 diabetes mellitus

The intervention showed no clear difference in all‐cause mortality a. Intervention vs metformin [a. 24 weeks to 4… (low certainty).

1 finding from 1 review

Intervention not reported

Cardiovascular mortality a. Intervention vs metformin [a. 24 weeks to 4 years] b. Intervention vs thiazolidinediones [b. 24 weeks to 4 years] c. Intervention vs insulin [c. 9 months to 10 years] d. Intervention vs meglitinide [d. 12 months to 17 m... · participants with type 2 diabetes mellitus

The intervention showed no clear difference in cardiovascular mortality a. Intervention vs metformin [a. 24 weeks… (low certainty).

1 finding from 1 review

Intervention not reported

Cardiovascular events · postmenopausal women with hypercholesterolaemia

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Death from any cause · postmenopausal women with hypercholesterolaemia

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Health‐related quality of life · postmenopausal women with hypercholesterolaemia

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Adverse events [ · postmenopausal women with hypercholesterolaemia
1 finding from 1 review

Intervention not reported

Low‐density lipoprotein (LDL) cholesterol [ · postmenopausal women with hypercholesterolaemia
1 finding from 1 review