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What do systematic reviews say?

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Evidence found and GRADE certainty

1,923 questions · 1,956 findings · 143 reviews · Musculoskeletal

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No studies found 555 · 28.4%GRADE not reported 107 · 5.5%Very low 255 · 13%Low 555 · 28.4%Moderate 357 · 18.3%High 127 · 6.5%

Balneotherapy vs drug treatment

Improvement Global improvement on 5‐point scale (very good/good/fair/poor/very poor) · patients with rheumatoid arthritis

It is very uncertain whether balneotherapy changes improvement Global improvement on 5‐point scale (very… compared with drug treatment (very low certainty).

1 finding from 1 review

Balneotherapy vs placebo

Improvement Yes/no based on 5 outcome measures (> 30% reduction in number of swollen joints, > 30% reduction in number of tender joints, > 20% improvement in patient VAS for severity of pain and > 20% improvement in physician VAS) · patients with rheumatoid arthritis

It is very uncertain whether balneotherapy changes improvement Yes/no based on 5 outcome measures (> 30% reduction in… compared with placebo (very low certainty).

1 finding from 1 review

Biofeedback vs usual care

Adverse events post‐intervention ‐ not reported · patients with fibromyalgia

The review found no eligible studies for this question.

1 finding from 1 review