Findings

What do systematic reviews say?

2,252 questions · 2,353 findings · 210 reviews · Neonatal

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No studies found 432 · 18.4%GRADE not reported 99 · 4.2%Very low 609 · 25.9%Low 737 · 31.3%Moderate 385 · 16.4%High 91 · 3.9%

Clonidine and opioid vs opioid

Neurodevelopmental disability · newborn infants with opioid withdrawal

The review found no eligible studies for this question.

1 finding from 1 review

Sedatives for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Clonidine and opioid vs opioid

Length of hospital stay · newborn infants with opioid withdrawal

The review found no eligible studies for this question.

1 finding from 1 review

Sedatives for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Clonidine and opioid vs opioid

Days' pharmacological treatment · newborn infants with opioid withdrawal

1 finding from 1 review

Sedatives for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 80 participants
Very low

Clonidine and opioid vs opioid

Adverse events (treatment related) To discharge · newborn infants with opioid withdrawal

It is very uncertain whether clonidine and opioid changes adverse events (treatment related) To discharge compared with opioid alone (very low certainty).

1 finding from 1 review

Sedatives for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
RR 3 [0.13, 71.51]
1 study · 80 participants
Very low

Clonidine and opioid vs phenobarbital and opioid

Treatment failure To discharge · newborn infants with opioid withdrawal

It is very uncertain whether clonidine and opioid changes treatment failure To discharge compared with phenobarbital and opioid (very low certainty).

1 finding from 1 review

Sedatives for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
RR 2.27 [0.98, 5.25]
2 studies · 93 participants
Very low

Clonidine and opioid vs phenobarbital and opioid

Seizures To discharge · newborn infants with opioid withdrawal

It is very uncertain whether clonidine and opioid changes seizures To discharge compared with phenobarbital and opioid (very low certainty).

1 finding from 1 review

Sedatives for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
RR 3 [0.13, 71.15]
1 study · 68 participants
Very low

Clonidine and opioid vs phenobarbital and opioid

Mortality before hospital discharge · newborn infants with opioid withdrawal

1 finding from 1 review

Sedatives for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 68 participants
Very low

Clonidine and opioid vs phenobarbital and opioid

Neurodevelopmental disability · newborn infants with opioid withdrawal

The review found no eligible studies for this question.

1 finding from 1 review

Sedatives for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Phenobarbital vs supportive care

Neurodevelopmental disability · newborn infants with opioid withdrawal

The review found no eligible studies for this question.

1 finding from 1 review

Sedatives for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Clonidine and opioid vs phenobarbital and opioid

Length of hospital stay · newborn infants with opioid withdrawal

1 finding from 1 review

Sedatives for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 91 participants
Low

Clonidine and opioid vs phenobarbital and opioid

Days' pharmacological treatment · newborn infants with opioid withdrawal

1 finding from 1 review

Sedatives for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 91 participants
Low

Clonidine and opioid vs phenobarbital and opioid

Adverse events (treatment related) To discharge · newborn infants with opioid withdrawal

It is very uncertain whether clonidine and opioid changes adverse events (treatment related) To discharge compared with phenobarbital and opioid (very low certainty).

1 finding from 1 review

Sedatives for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
RR 1.55 [0.44, 5.4]
2 studies · 93 participants
Very low

Phenobarbital vs supportive care

Length of hospital stay · newborn infants with opioid withdrawal

1 finding from 1 review

Sedatives for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 62 participants
Very low

Phenobarbital vs supportive care

Days' pharmacological treatment · newborn infants with opioid withdrawal

1 finding from 1 review

Sedatives for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 62 participants
Very low

Phenobarbital vs supportive care

Adverse events To discharge · newborn infants with opioid withdrawal

The review found no eligible studies for this question.

1 finding from 1 review

Sedatives for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Phenobarbital vs diazepam

Treatment failure To discharge · newborn infants with opioid withdrawal

Phenobarbital may leads to lower treatment failure To discharge compared with diazepam (low certainty).

1 finding from 1 review

Sedatives for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
RR 0.39 [0.24, 0.62]
2 studies · 139 participants
Low

Phenobarbital vs diazepam

Seizures To discharge · newborn infants with opioid withdrawal

The review found no eligible studies for this question.

1 finding from 1 review

Sedatives for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Opioids vs Placebo, no intervention or usual care (with or without placebo)

Treatment failure To discharge · newborn infants with opioid withdrawal

It is very uncertain whether opioid changes treatment failure To discharge compared with placebo or no treatment / usual care (very low certainty).

1 finding from 1 review

Opioid treatment for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
RR 1.29 [0.41, 4.07]
1 study · 80 participants
Very low

Morphine vs methadone

Neonatal or infant mortality · newborn infants with opioid withdrawal

The review found no eligible studies for this question.

1 finding from 1 review

Opioid treatment for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Morphine vs methadone

Neurodevelopmental disability · newborn infants with opioid withdrawal

The review found no eligible studies for this question.

1 finding from 1 review

Opioid treatment for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found