Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,079 questions · 2,112 findings · 171 reviews · Eyes and Vision

No studies found 587 · 27.8%GRADE not reported 95 · 4.5%Very low 446 · 21.1%Low 557 · 26.4%Moderate 361 · 17.1%High 66 · 3.1%

Radiotherapy vs control

Progression to visual loss (loss of 3 or more lines on logMAR chart) · people with neovascular AMD

Radiotherapy showed no clear difference in loss of 3 or more lines of best‐corrected visual acuity Measured… compared with control (low certainty).

1 finding from 1 review

Radiotherapy combined with anti‐VEGF vs anti‐VEGF alone

Progression to visual loss (loss of 3 or more lines on logMAR chart) · people with neovascular AMD

Radiotherapy combined with anti‐VEGF probably leads to higher loss of 3 or more lines of best‐corrected visual acuity Measured… compared with anti‐VEGF alone (moderate certainty).

1 finding from 1 review

Radiotherapy combined with anti‐VEGF vs anti‐VEGF alone

Change in visual acuity (logMAR) ‐ 12 months (negative is better) · people with neovascular AMD

Radiotherapy combined with anti‐VEGF showed no clear difference in change in best corrected visual acuity (logMAR units) Measured using… compared with anti‐VEGF alone (low certainty).

1 finding from 1 review

Intervention not reported

Undercorrected vs fully corrected spectacles · children with myopia (nearsightedness)
1 finding from 1 review

Intervention not reported

Systemic 7‐methylxanthine vs placebo · children with myopia (nearsightedness)
1 finding from 1 review

Intervention not reported

Atropine plus multifocal spectacles vs placebo plus SVLs · children with myopia (nearsightedness)
1 finding from 1 review

Intervention not reported

Atropine plus bifocal spectacles vs cyclopentolate plus SVLs · children with myopia (nearsightedness)
1 finding from 1 review

Intervention not reported

Bifocal spectacles vs SVLs with timolol drops · children with myopia (nearsightedness)
1 finding from 1 review