Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,079 questions · 2,112 findings · 171 reviews · Eyes and Vision

No studies found 587 · 27.8%GRADE not reported 95 · 4.5%Very low 446 · 21.1%Low 557 · 26.4%Moderate 361 · 17.1%High 66 · 3.1%

Systemic aminocaproic acid vs placebo

Short‐term visual acuity 20/40 or better ≤ 2 weeks after treatment · people with traumatic hyphema

Systemic aminocaproic acid showed no clear difference in short‐term visual acuity 20/40 or better ≤ 2 weeks after treatment compared with placebo (low certainty).

1 finding from 1 review

Topical aminocaproic acid vs placebo

Secondary hemorrhage at any time point · people with traumatic hyphema

Topical aminocaproic acid showed no clear difference in secondary hemorrhage at any time point compared with placebo (low certainty).

1 finding from 1 review

Systemic tranexamic acid vs control

Short‐term visual acuity 20/40 or better ≤ 2 weeks after treatment · people with traumatic hyphema

Systemic tranexamic acid showed no clear difference in short‐term visual acuity 20/40 or better ≤ 2 weeks after treatment compared with control (moderate certainty).

1 finding from 1 review

Systemic or topical corticosteroids vs placebo or control

Short‐term visual acuity between 20/20 and 20/40 ≤ 2 weeks after treatment; oral corticosteroids · people with traumatic hyphema

Systemic or topical corticosteroids showed no clear difference in short‐term visual acuity between 20/20 and 20/40 ≤ 2 weeks after… compared with placebo or control treatment (low certainty).

1 finding from 1 review

Systemic or topical corticosteroids vs placebo or control

Final visual acuity between 20/20 and 20/40 at end of treatment; oral corticosteroids · people with traumatic hyphema

Systemic or topical corticosteroids showed no clear difference in final visual acuity between 20/20 and 20/40 at end of treatment;… compared with placebo or control treatment (low certainty).

1 finding from 1 review

Systemic or topical corticosteroids vs placebo or control

Short‐term visual acuity between 20/20 and 20/40 ≤ 2 weeks after treatment; topical corticosteroids · people with traumatic hyphema

It is very uncertain whether systemic or topical corticosteroids changes short‐term visual acuity between 20/20 and 20/40 ≤ 2 weeks after… compared with placebo or control treatment (very low certainty).

1 finding from 1 review

Systemic or topical corticosteroids vs placebo or control

Final visual acuity between 20/20 and 20/25 at end of treatment; topical corticosteroids · people with traumatic hyphema

Systemic or topical corticosteroids showed no clear difference in final visual acuity between 20/20 and 20/25 at end of treatment;… compared with placebo or control treatment (low certainty).

1 finding from 1 review