Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,139 questions · 1,173 findings · 89 reviews · Neuromuscular

No studies found 302 · 25.7%GRADE not reported 119 · 10.1%Very low 267 · 22.8%Low 239 · 20.4%Moderate 177 · 15.1%High 69 · 5.9%

Corticosteroids vs placebo

Adverse effects requiring withdrawal/discontinuation of study medication · people with nerve damage (6 to 24 months' duration) in leprosy

Corticosteroids showed no clear difference in adverse events Assessed as adverse events requiring withdrawal of… compared with placebo (moderate certainty).

1 finding from 1 review

Corticosteroids vs placebo

Adverse events Assessed as: occurrence of one or more major adverse events requiring withdrawal of treatment · people with nerve damage (< 6 months' duration) in leprosy

Corticosteroids showed no clear difference in adverse events Assessed as: occurrence of one or more major adverse… compared with placebo (moderate certainty).

1 finding from 1 review

Corticosteroids vs placebo

Improvement in sensory nerve function at 1 year · people with nerve damage (6 to 24 months' duration) in leprosy

Corticosteroids showed no clear difference in improvement in sensory nerve function at 1 year compared with placebo (moderate certainty).

1 finding from 1 review

Clinical effect of simple decompression vs transposition

Proportion of patients with clinical improvement in function compared to baseline · patients with ulnar neuropathy at the elbow

Simple decompression showed no clear difference in proportion of participants with clinical improvement in function… compared with transposition (moderate certainty).

1 finding from 1 review

Clinical effect of simple decompression vs transposition

Proportion of patients with clinical improvement in function compared to baseline ‐ simple decompression versus subcutaneous transposition · patients with ulnar neuropathy at the elbow

Simple decompression showed no clear difference in subgroup: proportion of participants with clinical improvement in… compared with transposition (moderate certainty).

1 finding from 1 review

Clinical effect of simple decompression vs transposition

Subgroup: proportion of participants with clinical improvement in function compared to baseline ‐ simple decompression versus submuscular transposition · patients with ulnar neuropathy at the elbow

Simple decompression showed no clear difference in subgroup: proportion of participants with clinical improvement in… compared with transposition (moderate certainty).

1 finding from 1 review