Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,497 questions · 1,590 findings · 129 reviews · Gynaecological, Neuro-oncology and Orphan Cancer

No studies found 281 · 17.7%GRADE not reported 74 · 4.7%Very low 410 · 25.8%Low 420 · 26.4%Moderate 280 · 17.6%High 125 · 7.9%

Intervention not reported

Progression free survival · adults with glioblastoma

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Anxiety · adults with glioblastoma

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Quality of life · adults with glioblastoma

The review found no eligible studies for this question.

1 finding from 1 review

Two doses of HPV vaccine with longer interval vs two doses of HPV vaccine with shorter interval

High‐grade cervical, vulval, vaginal, penile, or anal intraepithelial neoplasia · 9‐ to 14‐year‐old females and males

The review found no eligible studies for this question.

1 finding from 1 review

Two doses of HPV vaccine with longer interval vs two doses of HPV vaccine with shorter interval

Serious adverse events at up to 5‐year · 9‐ to 14‐year‐old females and males

It is very uncertain whether two doses of HPV vaccine with longer interval changes serious adverse events at up to 5‐year compared with two doses of HPV vaccine with shorter interval (very low certainty).

1 finding from 1 review

Three doses HPV vaccine vs control

Penile or anal intraepithelial neoplasia at up to 3‐year · 10‐ to 26‐year‐old males

Three doses HPV vaccine showed no clear difference in penile or anal intraepithelial neoplasia at up to 3‐year compared with control (low certainty).

1 finding from 1 review

Three doses HPV vaccine vs control

External genital lesions (any genotype) at up to 3‐year · 10‐ to 26‐year‐old males

Three doses HPV vaccine probably leads to lower external genital lesions (any genotype) at up to 3‐year compared with control (moderate certainty).

1 finding from 1 review

Two doses of HPV vaccine vs three doses of HPV vaccine

Antibody response (immunogenicity) · 9‐ to 15‐year‐old females

Two doses of HPV vaccine probably leads to lower antibody response (immunogenicity) compared with three doses of HPV vaccine (moderate certainty).

1 finding from 1 review

Three doses HPV vaccine vs control

Overall systemic events and general symptoms · 10‐ to 26‐year‐old males

Three doses HPV vaccine showed no clear difference in overall systemic events and general symptoms at 15‐day compared with control (moderate certainty).

1 finding from 1 review