Findings

What do systematic reviews say?

1,139 questions · 1,173 findings · 89 reviews · Neuromuscular

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No studies found 302 · 25.7%GRADE not reported 119 · 10.1%Very low 267 · 22.8%Low 239 · 20.4%Moderate 177 · 15.1%High 69 · 5.9%

Intervention not reported

Rate of decline (per month) of functional rating scale (over a period of 9 months) Measured by ALSFRS‐R · people with ALS/MND

1 finding from 1 review

Gamma aminobutyric acid (GABA) modulators for amyotrophic lateral sclerosis/motor neuron disease 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 128 participants
Moderate

Intervention not reported

Health‐related quality of life Short Form 12 Health Survey (SF‐12) · people with ALS/MND

1 finding from 1 review

Gamma aminobutyric acid (GABA) modulators for amyotrophic lateral sclerosis/motor neuron disease 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 128 participants
Moderate

Intervention not reported

Adverse events · people with ALS/MND

1 finding from 1 review

Gamma aminobutyric acid (GABA) modulators for amyotrophic lateral sclerosis/motor neuron disease 2017 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 353 participants
High

Oxcarbazepine vs placebo

At least 50% reduction in pain · painful diabetic neuropathy

It is very uncertain whether oxcarbazepine changes reduction in participant‐reported pain scores by at least 50% from… compared with placebo (very low certainty).

1 finding from 1 review

Oxcarbazepine for neuropathic pain 2017 · Cochrane Headline outcomes only
RR 1.91 [1.08, 3.39]
1 study · 146 participants
Very low

Oxcarbazepine vs placebo

At least 30% reduction in pain · painful diabetic neuropathy

It is very uncertain whether oxcarbazepine changes reduction in participant‐reported pain scores by at least 30% from… compared with placebo (very low certainty).

1 finding from 1 review

Oxcarbazepine for neuropathic pain 2017 · Cochrane Headline outcomes only
RR 1.57 [1.01, 2.44]
1 study · 146 participants
Very low

Oxcarbazepine vs placebo

Participants' global impression of their change in pain Participant's global assessment of therapeutic effect, 'much' or 'very much' · painful diabetic neuropathy

It is very uncertain whether oxcarbazepine changes participants' global impression of their change in pain… compared with placebo (very low certainty).

1 finding from 1 review

Oxcarbazepine for neuropathic pain 2017 · Cochrane Headline outcomes only
RR 1.46 [1.13, 1.88]
2 studies · 493 participants
Very low

Oxcarbazepine vs placebo

Serious adverse effects · painful diabetic neuropathy

Oxcarbazepine probably leads to higher serious adverse effects compared with placebo (moderate certainty).

1 finding from 1 review

Oxcarbazepine for neuropathic pain 2017 · Cochrane Headline outcomes only
RR 3.65 [1.45, 9.2]
3 studies · 634 participants
Moderate

Low‐level laser therapy vs placebo

Overall improvement in CTS: SSS: short term (< 3 months) Scale from: 1 to 5 · carpal tunnel syndrome

1 finding from 1 review

Low‐level laser therapy for carpal tunnel syndrome 2017 · Cochrane Headline outcomes only
no estimate extracted
7 studies · 327 participants
Very low

Low‐level laser therapy vs ultrasound

Adverse events · carpal tunnel syndrome

The review found no eligible studies for this question.

1 finding from 1 review

Low‐level laser therapy for carpal tunnel syndrome 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Low‐level laser therapy vs fascial manipulation

Overall improvement in CTS: SSS: short term (< 3 months) Scale from: 1 to 5 · carpal tunnel syndrome

1 finding from 1 review

Low‐level laser therapy for carpal tunnel syndrome 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 70 participants
Very low

Low‐level laser therapy vs fascial manipulation

Overall improvement in CTS: SSS: long term Scale from: 1 to 5 · carpal tunnel syndrome

The review found no eligible studies for this question.

1 finding from 1 review

Low‐level laser therapy for carpal tunnel syndrome 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Low‐level laser therapy vs fascial manipulation

Overall improvement in CTS: FSS: short term (< 3 months) Scale from: 1 to 5 · carpal tunnel syndrome

1 finding from 1 review

Low‐level laser therapy for carpal tunnel syndrome 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 70 participants
Very low

Low‐level laser therapy vs fascial manipulation

Overall improvement in CTS: FSS: long term Scale from: 1 to 5 · carpal tunnel syndrome

The review found no eligible studies for this question.

1 finding from 1 review

Low‐level laser therapy for carpal tunnel syndrome 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Low‐level laser therapy vs fascial manipulation

Adverse events · carpal tunnel syndrome

The review found no eligible studies for this question.

1 finding from 1 review

Low‐level laser therapy for carpal tunnel syndrome 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Low‐level laser therapy and a splint vs ultrasound and a splint

Overall improvement in CTS: SSS: short term (< 3 months) Scale from: 1 to 5 · carpal tunnel syndrome

1 finding from 1 review

Low‐level laser therapy for carpal tunnel syndrome 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 66 participants
Very low

Low‐level laser therapy and a splint vs ultrasound and a splint

Overall improvement in CTS: SSS: long term ‐ not measured · carpal tunnel syndrome

The review found no eligible studies for this question.

1 finding from 1 review

Low‐level laser therapy for carpal tunnel syndrome 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Low‐level laser therapy and a splint vs ultrasound and a splint

Overall improvement in CTS: FSS: short term (< 3 months) Scale from: 1 to 5 · carpal tunnel syndrome

1 finding from 1 review

Low‐level laser therapy for carpal tunnel syndrome 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 66 participants
Very low

Low‐level laser therapy and a splint vs ultrasound and a splint

Overall improvement in CTS: FSS: long term ‐ not reported · carpal tunnel syndrome

The review found no eligible studies for this question.

1 finding from 1 review

Low‐level laser therapy for carpal tunnel syndrome 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Low‐level laser therapy vs placebo

Overall improvement in CTS: SSS: long term Scale from: 1 to 5 · carpal tunnel syndrome

1 finding from 1 review

Low‐level laser therapy for carpal tunnel syndrome 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 25 participants
Very low

Low‐level laser therapy and a splint vs ultrasound and a splint

Adverse events · carpal tunnel syndrome

The review found no eligible studies for this question.

1 finding from 1 review

Low‐level laser therapy for carpal tunnel syndrome 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found