Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,497 questions · 1,590 findings · 129 reviews · Gynaecological, Neuro-oncology and Orphan Cancer

No studies found 281 · 17.7%GRADE not reported 74 · 4.7%Very low 410 · 25.8%Low 420 · 26.4%Moderate 280 · 17.6%High 125 · 7.9%

Intervention not reported

BEV_CRT (1 RCT; 73 participants) · elderly people with newly diagnosed glioblastoma Interventions: radiotherapy with 40 Gy in 15 fractions (RT 40); chemoradiotherapy (CRT);…

The intervention led to lower BEV_CRT (1 RCT; 73 participants); GRADE not reported.

1 finding from 1 review

Intervention not reported

RT60 (5 RCTs; 713 participants) · elderly people with newly diagnosed glioblastoma Interventions: radiotherapy with 40 Gy in 15 fractions (RT40); radiotherapy with 60 Gy in…

The intervention probably leads to lower RT60 (5 RCTs; 713 participants) (moderate certainty).

1 finding from 1 review

Intervention not reported

RT vs supportive care only · elderly people with newly diagnosed glioblastoma Interventions: one treatment option Comparison: an alternative treatment option

The intervention probably leads to lower RT vs supportive care only (moderate certainty).

1 finding from 1 review

Intervention not reported

Hypofractionated RT vs standard RT (60Gy/30 fractions) · elderly people with newly diagnosed glioblastoma Interventions: one treatment option Comparison: an alternative treatment option

The intervention led to lower hypofractionated RT vs standard RT (60Gy/30 fractions); GRADE not reported.

1 finding from 1 review

Intervention not reported

BEV_RT (1 RCT; 75 participants) · elderly people with newly diagnosed glioblastoma Interventions: radiotherapy with 40 Gy in 15 fractions (RT40); radiotherapy with 60 Gy in…

The intervention showed no clear difference in BEV_RT (1 RCT; 75 participants); GRADE not reported.

1 finding from 1 review

Intervention not reported

TMZ vs RT · elderly people with newly diagnosed glioblastoma Interventions: one treatment option Comparison: an alternative treatment option

The intervention showed no clear difference in TMZ vs RT (low certainty).

1 finding from 1 review

Intervention not reported

CRT vs RT · elderly people with newly diagnosed glioblastoma Interventions: one treatment option Comparison: an alternative treatment option

The intervention leads to lower CRT vs RT (high certainty).

1 finding from 1 review

Intervention not reported

BEV_CRT vs CRT · elderly people with newly diagnosed glioblastoma Interventions: one treatment option Comparison: an alternative treatment option

The intervention showed no clear difference in BEV_CRT vs CRT (low certainty).

1 finding from 1 review

Intervention not reported

BEV_RT vs RT · elderly people with newly diagnosed glioblastoma Interventions: one treatment option Comparison: an alternative treatment option

The intervention probably leads to lower BEV_RT vs RT (moderate certainty).

1 finding from 1 review

Intervention not reported

RIN_CRT vs CRT · elderly people with newly diagnosed glioblastoma Interventions: one treatment option Comparison: an alternative treatment option

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

TTF_AC vs CRT · elderly people with newly diagnosed glioblastoma Interventions: one treatment option Comparison: an alternative treatment option

The review found no eligible studies for this question.

1 finding from 1 review