Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,252 questions · 2,353 findings · 210 reviews · Neonatal

No studies found 432 · 18.4%GRADE not reported 99 · 4.2%Very low 609 · 25.9%Low 737 · 31.3%Moderate 385 · 16.4%High 91 · 3.9%

Phenobarbital vs phenytoin

Proportion of infants who develop sedation or drowsiness · neonates with clinically diagnosed seizures

It is very uncertain whether summary of findings table ‐ Phenobarbital changes proportion of infants who develop sedation or drowsiness compared with phenytoin (very low certainty).

1 finding from 1 review

Phenobarbital vs lorazepam

Proportion of infants who achieve seizure control after the first loading dose of ASM · neonates with clinically diagnosed seizures

It is very uncertain whether summary of findings table ‐ Phenobarbital changes proportion of infants who achieve seizure control after the first… compared with lorazepam (very low certainty).

1 finding from 1 review

Phenobarbital vs lorazepam

Mortality before hospital discharge · neonates with clinically diagnosed seizures

It is very uncertain whether summary of findings table ‐ Phenobarbital changes mortality before hospital discharge compared with lorazepam (very low certainty).

1 finding from 1 review

Phenobarbital vs lorazepam

Proportion of infants who develop sedation or drowsiness · neonates with clinically diagnosed seizures

It is very uncertain whether summary of findings table ‐ Phenobarbital changes proportion of infants who develop sedation or drowsiness compared with lorazepam (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Phenytoin vs lorazepam

Proportion of infants who achieve seizure control after the first loading dose of ASM · neonates with clinically diagnosed seizures

It is very uncertain whether summary of findings table ‐ Phenytoin changes proportion of infants who achieve seizure control after the first… compared with lorazepam (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Phenytoin vs lorazepam

Proportion of infants who develop sedation or drowsiness · neonates with clinically diagnosed seizures

It is very uncertain whether summary of findings table ‐ Phenytoin changes proportion of infants who develop sedation or drowsiness compared with lorazepam (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Phenobarbital + bumetanide vs phenobarbital

Proportion of infants who achieve seizure control after the first loading dose of ASM · neonates with EEG‐confirmed seizures

Summary of findings table ‐ Phenobarbital + bumetanide showed no clear difference in proportion of infants who achieve seizure control after the first… compared with phenobarbital alone (low certainty).

1 finding from 1 review

Summary of findings table ‐ Phenobarbital + bumetanide vs phenobarbital

Mortality before hospital discharge · neonates with EEG‐confirmed seizures

It is very uncertain whether summary of findings table ‐ Phenobarbital + bumetanide changes mortality before hospital discharge compared with phenobarbital alone (very low certainty).

1 finding from 1 review

Phenobarbital vs levetiracetam

Mortality before hospital discharge · neonates with EEG‐confirmed seizures

It is very uncertain whether summary of findings table ‐ Phenobarbital changes mortality before hospital discharge compared with levetiracetam (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Phenobarbital + bumetanide vs phenobarbital

Proportion of infants who develop epilepsy post‐discharge · neonates with EEG‐confirmed seizures

It is very uncertain whether summary of findings table ‐ Phenobarbital + bumetanide changes proportion of infants who develop epilepsy post‐discharge compared with phenobarbital alone (very low certainty).

1 finding from 1 review