Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,234 questions · 2,325 findings · 216 reviews · Airways

No studies found 249 · 10.7%GRADE not reported 107 · 4.6%Very low 276 · 11.9%Low 751 · 32.3%Moderate 718 · 30.9%High 224 · 9.6%

Anti‐IL13 or anti‐IL4 agents vs placebo

Exacerbation requiring ED or hospital visit Weighted mean duration of studies: 31 weeks · people with asthma

Anti‐IL13 or anti‐IL4 agents probably leads to lower exacerbation requiring hospitalisation or ED visit compared with placebo (moderate certainty).

1 finding from 1 review

Intervention not reported

Post hoc exploratory endpoint: Exacerbation requiring hospitalisation/ED/OCS (rate ratio) · children and adults with asthma

The intervention may leads to lower post hoc exploratory endpoint: Exacerbation requiring… (low certainty).

1 finding from 1 review

Anti‐IL13 or anti‐IL4 agents vs placebo

Rate of exacerbations requiring systemic corticosteroids · people with asthma

Anti‐IL13 or anti‐IL4 agents showed no clear difference in exacerbation requiring OCS (rate ratio) compared with placebo (low certainty).

1 finding from 1 review

Telerehabilitation vs no rehabilitation control

Exercise capacity · Chronic respiratory disease

Telerehabilitation may leads to higher exercise capacity ‐ 6MWD (m) compared with no rehabilitation control (low certainty).

2 findings from 1 review

Telerehabilitation vs no rehabilitation control

Dyspnea · Chronic respiratory disease

It is very uncertain whether telerehabilitation changes dyspnoea ‐ mMRC compared with no rehabilitation control (very low certainty).

2 findings from 1 review