Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,293 questions · 2,395 findings · 172 reviews · Gut

No studies found 420 · 17.5%GRADE not reported 60 · 2.5%Very low 821 · 34.3%Low 602 · 25.1%Moderate 397 · 16.6%High 95 · 4%

Probiotics vs magnesium oxide

Global improvement or treatment success, as defined by primary study · children with chronic constipation without a physical explanation

It is very uncertain whether probiotics changes global improvement/treatment success, as defined by the primary study compared with magnesium oxide (very low certainty).

1 finding from 1 review

Synbiotic vs placebo

Global improvement or treatment success, as defined by primary study · children with chronic constipation without a physical explanation

Synbiotics may leads to higher global improvement or treatment success, as defined by primary study compared with placebo (low certainty).

1 finding from 1 review

Synbiotics and paraffin vs paraffin

Global assessment of treatment success · children with chronic constipation without a physical explanation

It is very uncertain whether synbiotics and paraffin changes global improvement or treatment success, as defined by primary studies compared with paraffin (very low certainty).

1 finding from 1 review

Probiotics vs placebo

Global improvement or treatment success, as defined by primary study · children with chronic constipation without a physical explanation

Probiotic may leads to higher global improvement/treatment success as defined by primary study compared with placebo (low certainty).

1 finding from 1 review

Synbiotic vs paraffin

Global assessment of treatment success · children with chronic constipation without a physical explanation

It is very uncertain whether synbiotics changes global improvement or treatment success, as defined by primary studies compared with paraffin (very low certainty).

1 finding from 1 review

Probiotics vs placebo

Withdrawals due to adverse events · children with chronic constipation without a physical explanation

Probiotic showed no clear difference in withdrawals due to adverse events compared with placebo (low certainty).

1 finding from 1 review

Probiotics and osmotic laxative vs osmotic laxative

Global assessment of treatment success · children with chronic constipation without a physical explanation

Probiotics and osmotic laxative showed no clear difference in global improvement or treatment success, as defined by primary studies compared with osmotic laxative (low certainty).

1 finding from 1 review