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Evidence found and GRADE certainty

582 questions · 664 findings · 25 reviews · Endodontics and dental trauma

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No studies found 111 · 16.7%GRADE not reported 417 · 62.8%Very low 69 · 10.4%Low 50 · 7.5%Moderate 16 · 2.4%High 1 · 0.2%

Papilla base incision (PBI) vs Complete papilla mobilisation (sulcular incision)

Postoperative pain (VAS 0-100) - 3 days · People requiring retreatment of periapical lesions (failed root canal therapy)

Papilla base incision (PBI) led to lower postoperative pain (VAS 0-100) - 3 days compared with complete papilla mobilisation (sulcular incision); GRADE not reported.

1 finding from 1 review

Platelet-rich fibrin (PRF) graft vs No grafting

Radiographic healing - 1 year · People requiring retreatment of periapical lesions (failed root canal therapy)
1 finding from 1 review
  • Endodontic procedures for retreatment of periapical lesions 2016 · Cochrane All outcomes
    1 year
    Angerame 2015 (7 test, 4 control): no significant difference in healing of the lesion at 1 year; significant difference only at 2- and 3-month follow-up. Small preliminary study; no robust pooled analysis.
    1 study · 11 participants
    GRADE not reported

Cone beam computed tomography (CBCT) preoperative evaluation vs Conventional periapical radiography

Healing - 1 year · People requiring retreatment of periapical lesions (failed root canal therapy)

It is very uncertain whether cone beam computed tomography (CBCT) preoperative evaluation changes healing - 1 year compared with conventional periapical radiography (very low certainty).

1 finding from 1 review

Mineral trioxide aggregate (MTA) root-end filling vs Intermediate restorative material (IRM)

Prevalence of pain - 1 day · People requiring retreatment of periapical lesions (failed root canal therapy)

Mineral trioxide aggregate (MTA) root-end filling showed no clear difference in prevalence of pain - 1 day compared with intermediate restorative material (IRM) (low certainty).

1 finding from 1 review

Papilla base incision (PBI) vs Complete papilla mobilisation (sulcular incision)

Postoperative pain (VAS 0-100) - 2 days · People requiring retreatment of periapical lesions (failed root canal therapy)

Papilla base incision (PBI) showed no clear difference in postoperative pain (VAS 0-100) - 2 days compared with complete papilla mobilisation (sulcular incision); GRADE not reported.

1 finding from 1 review

Papilla base incision (PBI) vs Complete papilla mobilisation (sulcular incision)

Postoperative pain (VAS 0-100) - 1 day · People requiring retreatment of periapical lesions (failed root canal therapy)

It is very uncertain whether papilla base incision (PBI) changes postoperative pain (VAS 0-100) - 1 day compared with complete papilla mobilisation (sulcular incision) (very low certainty).

1 finding from 1 review

Preoperative antibiotics vs placebo

Occurrence of postoperative infection - 4 weeks · People requiring retreatment of periapical lesions (failed root canal therapy)

It is very uncertain whether preoperative antibiotic prophylaxis changes occurrence of postoperative infection - 4 weeks compared with placebo (very low certainty).

1 finding from 1 review

Mineral trioxide aggregate (MTA) root-end filling vs Intermediate restorative material (IRM)

Healing rate · People requiring retreatment of periapical lesions (failed root canal therapy)

Mineral trioxide aggregate (MTA) root-end filling showed no clear difference in healing - 2 years compared with intermediate restorative material (IRM); GRADE not reported.

1 finding from 1 review

Root-end resection (with or without root-end filling; surgical retreatment) vs Non-surgical re-treatment (orthograde root canal therapy)

Healing rate · People with one or more endodontically treated teeth and a periapical condition requiring retreatment

Root-end resection (with or without root-end filling; surgical… showed no clear difference in healing - 10 years compared with root canal retreatment (non-surgical/orthograde); GRADE not reported.

2 findings from 1 review

Papilla base incision (PBI) vs Complete papilla mobilisation (sulcular incision)

Height loss of interdental papilla - 1 year · People requiring retreatment of periapical lesions (failed root canal therapy)

It is very uncertain whether papilla base incision (PBI) changes height loss of interdental papilla - 1 year compared with complete papilla mobilisation (sulcular incision) (very low certainty).

1 finding from 1 review

Guided tissue regeneration (GTR) with bovine bone mineral + resorbable collagen membrane vs No GTR (no grafting)

Healing - 1 year · People requiring retreatment of periapical lesions (failed root canal therapy)

Guided tissue regeneration (GTR) with bovine bone mineral +… showed no clear difference in healing - 1 year compared with no GTR (no grafting) (low certainty).

1 finding from 1 review

Placebo (sham irradiation, laser inactive) vs Control (no laser device used)

Maximum pain (verbal rating scale, VRS) · People requiring retreatment of periapical lesions (failed root canal therapy)

Placebo (sham irradiation, laser inactive) led to lower maximum pain (verbal rating scale, VRS) compared with control (no laser device used); GRADE not reported.

1 finding from 1 review

Mineral trioxide aggregate (MTA) root-end filling vs Gutta-percha smoothing (orthograde GP root filling)

Postoperative pain (VAS 0-100) - 1 day · People requiring retreatment of periapical lesions (failed root canal therapy)

Mineral trioxide aggregate (MTA) root-end filling showed no clear difference in postoperative pain (VAS 0-100) - 1 day compared with gutta-percha smoothing (orthograde GP root filling) (low certainty).

1 finding from 1 review