What do systematic reviews say?

Triple therapy vs LABA/LAMA combination

Triple therapy showed no clear difference in all‐cause SAEs compared with LABA/LAMA combination (low certainty).

• Inhaled corticosteroids with combination inhaled long‐acting beta2‐agonists and long‐acting muscarinic antagonists for… 2023 · Cochrane Headline outcomes only
  OR 0.95 [0.87, 1.03]
  4 studies · 15412 participants
  Low

Triple therapy vs LABA/LAMA combination

Triple therapy probably leads to higher symptom score TDI, ≥ 1‐unit increase (lower scores indicate worse… compared with LABA/LAMA combination (moderate certainty).

• Inhaled corticosteroids with combination inhaled long‐acting beta2‐agonists and long‐acting muscarinic antagonists for… 2023 · Cochrane Headline outcomes only
  OR 1.33 [1.13, 1.57]
  1 study · 3044 participants
  Moderate

Triple therapy vs LABA/LAMA combination

Triple therapy may leads to higher lung function, change in trough FEV1 (mL) compared with LABA/LAMA combination (low certainty).

• Inhaled corticosteroids with combination inhaled long‐acting beta2‐agonists and long‐acting muscarinic antagonists for… 2023 · Cochrane Headline outcomes only
  MD 38.68 [22.58, 54.77]
  4 studies · 11352 participants
  Low

Triple therapy vs LABA/LAMA combination

Triple therapy may leads to lower mortality (all‐cause) compared with LABA/LAMA combination (low certainty).

• Inhaled corticosteroids with combination inhaled long‐acting beta2‐agonists and long‐acting muscarinic antagonists for… 2023 · Cochrane Headline outcomes only
  OR 0.7 [0.54, 0.9]
  4 studies · 15397 participants
  Low

Intensity of glycaemic control for women with gestational diabetes mellitus ‐ strict glycaemic targets vs less‐tight glycaemic targets (maternal outcomes)

Intensity of glycaemic control for women with gestational diabetes… showed no clear difference in hypertensive disorders of pregnancy (including pre‐eclampsia,… compared with less‐tight glycaemic targets (maternal outcomes) (low certainty).

• Different intensities of glycaemic control for women with gestational diabetes mellitus 2023 · Cochrane Headline outcomes only
  RR 1.16 [0.8, 1.69]
  2 studies · 1491 participants
  Low

Intensity of glycaemic control for women with gestational diabetes mellitus ‐ strict glycaemic targets vs less‐tight glycaemic targets (child (as neonate, child, adult) outcomes)

Intensity of glycaemic control for women with gestational diabetes… showed no clear difference in composite of mortality or serious morbidity (as defined by trial) compared with less‐tight glycaemic targets (child (as neonate, child, adult)… (low certainty).

• Different intensities of glycaemic control for women with gestational diabetes mellitus 2023 · Cochrane Headline outcomes only
  RR 0.84 [0.55, 1.29]
  3 studies · 1559 participants
  Low

Intensity of glycaemic control for women with gestational diabetes mellitus ‐ strict glycaemic targets vs less‐tight glycaemic targets (child (as neonate, child, adult) outcomes)

The review found no eligible studies for this question.

• Different intensities of glycaemic control for women with gestational diabetes mellitus 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intensity of glycaemic control for women with gestational diabetes mellitus ‐ strict glycaemic targets vs less‐tight glycaemic targets (child (as neonate, child, adult) outcomes)

Intensity of glycaemic control for women with gestational diabetes… showed no clear difference in infant hypoglycaemia compared with less‐tight glycaemic targets (child (as neonate, child, adult)… (moderate certainty).

• Different intensities of glycaemic control for women with gestational diabetes mellitus 2023 · Cochrane Headline outcomes only
  RR 0.92 [0.72, 1.18]
  3 studies · 1556 participants
  Moderate

Intensity of glycaemic control for women with gestational diabetes mellitus ‐ strict glycaemic targets vs less‐tight glycaemic targets (child (as neonate, child, adult) outcomes)

• Different intensities of glycaemic control for women with gestational diabetes mellitus 2023 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 60 participants
  Low

Intensity of glycaemic control for women with gestational diabetes mellitus ‐ strict glycaemic targets vs less‐tight glycaemic targets (child (as neonate, child, adult) outcomes)

The review found no eligible studies for this question.

• Different intensities of glycaemic control for women with gestational diabetes mellitus 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intensity of glycaemic control for women with gestational diabetes mellitus ‐ strict glycaemic targets vs less‐tight glycaemic targets (maternal outcomes)

The review found no eligible studies for this question.

• Different intensities of glycaemic control for women with gestational diabetes mellitus 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intensity of glycaemic control for women with gestational diabetes mellitus ‐ strict glycaemic targets vs less‐tight glycaemic targets (maternal outcomes)

• Different intensities of glycaemic control for women with gestational diabetes mellitus 2023 · Cochrane Headline outcomes only
  0.98 [0.82, 1.17]
  3 studies · 1662 participants
  Moderate

Intensity of glycaemic control for women with gestational diabetes mellitus ‐ strict glycaemic targets vs less‐tight glycaemic targets (maternal outcomes)

The review found no eligible studies for this question.

• Different intensities of glycaemic control for women with gestational diabetes mellitus 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intensity of glycaemic control for women with gestational diabetes mellitus ‐ strict glycaemic targets vs less‐tight glycaemic targets (maternal outcomes)

Intensity of glycaemic control for women with gestational diabetes… showed no clear difference in induction of labour compared with less‐tight glycaemic targets (maternal outcomes) (moderate certainty).

• Different intensities of glycaemic control for women with gestational diabetes mellitus 2023 · Cochrane Headline outcomes only
  RR 0.96 [0.78, 1.18]
  1 study · 1096 participants
  Moderate

Intensity of glycaemic control for women with gestational diabetes mellitus ‐ strict glycaemic targets vs less‐tight glycaemic targets (maternal outcomes)

The review found no eligible studies for this question.

• Different intensities of glycaemic control for women with gestational diabetes mellitus 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intensity of glycaemic control for women with gestational diabetes mellitus ‐ strict glycaemic targets vs less‐tight glycaemic targets (maternal outcomes)

The review found no eligible studies for this question.

• Different intensities of glycaemic control for women with gestational diabetes mellitus 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intensity of glycaemic control for women with gestational diabetes mellitus ‐ strict glycaemic targets vs less‐tight glycaemic targets (child (as neonate, child, adult) outcomes)

• Different intensities of glycaemic control for women with gestational diabetes mellitus 2023 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 1499 participants
  Low

Intensity of glycaemic control for women with gestational diabetes mellitus ‐ strict glycaemic targets vs less‐tight glycaemic targets (child (as neonate, child, adult) outcomes)

Intensity of glycaemic control for women with gestational diabetes… showed no clear difference in large‐for‐gestational‐age compared with less‐tight glycaemic targets (child (as neonate, child, adult)… (moderate certainty).

• Different intensities of glycaemic control for women with gestational diabetes mellitus 2023 · Cochrane Headline outcomes only
  RR 0.96 [0.72, 1.29]
  3 studies · 1556 participants
  Moderate

Amlodipine plus standard iron chelation therapy vs standard chelation therapy with or without placebo

• Calcium channel blockers for preventing cardiomyopathy due to iron overload in people with transfusion‐dependent beta… 2023 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 191 participants
  Low

Amlodipine plus standard iron chelation therapy vs standard chelation therapy with or without placebo

• Calcium channel blockers for preventing cardiomyopathy due to iron overload in people with transfusion‐dependent beta… 2023 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 138 participants
  Low