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Evidence found and GRADE certainty

3,556 questions · 10,375 findings · 429 reviews · All outcomes

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No studies found 1,344 · 13%GRADE not reported 6,832 · 65.9%Very low 1,228 · 11.8%Low 613 · 5.9%Moderate 290 · 2.8%High 68 · 0.7%

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Topical triamcinolone acetonide vs Hyaluronic acid gel

Pain (mean score) · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment

Topical triamcinolone acetonide showed no clear difference in pain (mean score) compared with hyaluronic acid gel; GRADE not reported.

1 finding from 1 review

Intervention not reported

Dental caries in permanent teeth · Children (permanent dentition) worldwide

In Australia, the pooled estimate of permanent-teeth caries prevalence in children was 54.9% (95% CI 50.9 to 58.8) from a single study; certainty not graded.

1 finding from 1 review

Absence (previous removal or agenesis) of asymptomatic disease-free impacted wisdom teeth vs Retention (conservative management) of asymptomatic disease-free impacted wisdom teeth

Periodontitis (distal alveolar bone loss, adjacent second molar) · Adults (416 healthy male volunteers aged 24 to 84 years) with asymptomatic disease-free impacted wisdom teeth

It is very uncertain whether absence (previous removal or agenesis) of asymptomatic disease-free… changes periodontitis (distal alveolar bone loss, adjacent second molar) compared with presence (retention) of asymptomatic disease-free impacted wisdom… (very low certainty).

1 finding from 1 review

Blue fluorescence devices (VistaProof, SoproLife, Spectra; wavelength 400-450 nm) vs Reference standard (histology, excavation, or enhanced visual examination)

Diagnostic accuracy (sensitivity and specificity) for detection of early enamel caries (D1 threshold) · Asymptomatic children, adolescents, or adults presenting for clinical examination (in vivo studies), or extracted teeth of children or…
1 finding from 1 review
  • Fluorescence devices for the detection of dental caries 2020 · Cochrane All outcomes
    Up to 3 months between index test and reference standard (in vivo studies)
    Analysed as a separate index test (coupled forest plot and SROC plot, Figure 24 / Figure 25; Appendix 5); no summary DOR or sensitivity/specificity point reported numerically in the text. 3 datasets, 1027 tooth sites.
    3 studies
    GRADE not reported

Amoxicillin + clavulanate + SRP vs Tetracycline + SRP

Percentage of bleeding on probing (BOP) · Adults with aggressive periodontitis

Amoxicillin + clavulanate + SRP showed no clear difference in percentage of bleeding on probing (BOP) compared with tetracycline + SRP; GRADE not reported.

1 finding from 1 review

Any antimicrobial mouthwash and/or nasal spray (alone or in combination), at any concentration, delivered to healthcare workers, with or without the same intervention given to the patients with COVID-19 vs No treatment or saline or water

Incidence of symptomatic or test-positive COVID-19 infection in HCWs · Healthcare workers (HCWs) treating patients with suspected or confirmed COVID-19 infection

The review found no eligible studies for this question.

1 finding from 1 review

Clinical examination with 24-month recall vs Clinical examination with 12-month recall

Oral health-related quality of life · Regular-attending primary-care dental patients aged 3, 16 or 18 years at entry (aged up to 20; low caries risk)

The review found no eligible studies for this question.

1 finding from 1 review

Integrated Chinese and Western medicine (incl. oral prednisone) vs Western medicine (incl. oral prednisone)

Clinical score · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment
1 finding from 1 review

Absence (previous removal or agenesis) of asymptomatic disease-free impacted wisdom teeth vs Retention (conservative management) of asymptomatic disease-free impacted wisdom teeth

Periodontitis (distal probing depth greater than 4 mm, adjacent second molar) · Adults (416 healthy male volunteers aged 24 to 84 years) with asymptomatic disease-free impacted wisdom teeth

It is very uncertain whether absence (previous removal or agenesis) of asymptomatic disease-free… changes periodontitis (distal probing depth greater than 4 mm, adjacent… compared with presence (retention) of asymptomatic disease-free impacted wisdom… (very low certainty).

1 finding from 1 review