What do systematic reviews say?

Intervention not reported

• Success rate of proximal tooth-coloured direct restorations in primary teeth at 24 months: a meta-analysis. 2020 All outcomes

  Material type: Resin-based material + self-etching adhesion
  Proportion 0.916 [0.848, 0.956]
  8 studies
  GRADE not reported

Clinical examination with risk-based recall vs Clinical examination with 6-month recall

Clinical examination with risk-based recall showed no clear difference in oral health attitudes (1-7 scale) compared with clinical examination with 6-month recall; GRADE not reported.

• Recall intervals for oral health in primary care patients 2020 · Cochrane All outcomes

  4 years
  MD 0.04 [-0.04, 0.12]
  1 study · 1607 participants
  GRADE not reported

Clinical examination with 24-month recall vs Clinical examination with 6-month recall

Clinical examination with 24-month recall showed no clear difference in periodontal disease: probing pocket depth (mm) compared with clinical examination with 6-month recall (moderate certainty).

• Recall intervals for oral health in primary care patients 2020 · Cochrane All outcomes

  4 years
  MD -0.03 [-0.12, 0.06]
  1 study · 270 participants
  Moderate

Counter-stimulation or distraction vs Conventional treatment

The review found no eligible studies for this question.

• Interventions for increasing acceptance of local anaesthetic in children and adolescents having dental treatment 2020 · Cochrane All outcomes

  Immediately before or during LA
  Successful LA/painless treatment: included studies did not report on this outcome
  Studies not reported
  No studies found

Clinical examination with 24-month recall vs Clinical examination with 6-month recall

Clinical examination with 24-month recall showed no clear difference in oral-health-related quality of life (OHIP-14) compared with clinical examination with 6-month recall (high certainty).

• Recall intervals for oral health in primary care patients 2020 · Cochrane All outcomes

  4 years
  MD -0.24 [-1.55, 1.07]
  1 study · 305 participants
  High

Antimicrobial coolant A (chlorhexidine) vs povidone‐iodine

It is very uncertain whether antimicrobial coolant A (chlorhexidine) changes reduction in level of contamination in aerosols (CFU): chlorhexidine… compared with antimicrobial coolant B (povidone iodine) (very low certainty).

• Interventions to reduce contaminated aerosols produced during dental procedures for preventing infectious diseases 2020 · Cochrane All outcomes
  MD -59.30 [-64.16, -54.44]
  1 study · 20 participants
  Very low

Saline rinse vs usual or supportive care

Saline rinse showed no clear difference in duration of mechanical ventilation compared with usual care (no rinse); GRADE not reported.

• Oral hygiene care for critically ill patients to prevent ventilator‐associated pneumonia 2020 · Cochrane All outcomes
  MD -0.40 [-2.55, 1.75]
  2 studies · 324 participants
  GRADE not reported

Intervention not reported

• Success rate of proximal tooth-coloured direct restorations in primary teeth at 24 months: a meta-analysis. 2020 All outcomes

  Material type: Resin-based material + self-etching adhesion
  Proportion 0.926 [0.829, 0.970]
  6 studies
  GRADE not reported

Intervention not reported

• Success rate of proximal tooth-coloured direct restorations in primary teeth at 24 months: a meta-analysis. 2020 All outcomes

  Financial source: Public
  Proportion 0.919 [0.846, 0.959]
  10 studies
  GRADE not reported

Tetracycline + SRP vs SRP

The review found no eligible studies for this question.

• Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes

  Long-term (≥ 1 year)
  Included studies have not reported this outcome
  Studies not reported
  No studies found

CT + TT genotype (T-allele carriers) of AMELX rs6639060 vs CC genotype

The pooled odds ratio was 1.14 (95% CI 0.56 to 2.29).

• Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. 2020 All outcomes

  Ethnicity: Caucasian (n=1)
  OR 1.14 [0.56, 2.29]
  1 study
  GRADE not reported

Periodontal disease (present) vs Individuals without periodontal disease (by LOA)

Periodontal disease was associated with higher odds of poor OHRQoL (OR 1.15, 95% CI 1.12-1.18; 3 studies; no heterogeneity; ungraded).

• The Association of Oral Health Status, demographic characteristics and socioeconomic determinants with Oral… 2020 All outcomes

  Upper-middle-income countries (Brazil); studies 2010-2014
  OR 1.15 [1.12, 1.18]
  3 studies
  GRADE not reported

Antimicrobial coolant A (chlorhexidine) vs Antimicrobial coolant B (cinnamon extract)

It is very uncertain whether antimicrobial coolant A (chlorhexidine) changes reduction in level of contamination in aerosols (CFU): chlorhexidine… compared with antimicrobial coolant B (cinnamon extract) (very low certainty).

• Interventions to reduce contaminated aerosols produced during dental procedures for preventing infectious diseases 2020 · Cochrane All outcomes
  MD -11.90 [-35.88, 12.08]
  1 study · 40 participants
  Very low

Moxifloxacin + SRP vs SRP

Moxifloxacin + SRP led to lower probing pocket depth compared with SRP; GRADE not reported.

• Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes

  Intermediate-term (> 3 months to < 1 year)
  MD -0.42 [-0.74, -0.10]
  1 study · 40 participants
  GRADE not reported

CT + TT genotype (T-allele carriers) of ENAM rs3796703 vs CC genotype of ENAM rs3796703

No significant association between CT + TT genotype (T-allele carriers) vs CC genotype of ENAM rs3796703 and dental caries susceptibility (CT + TT vs CC model: OR 0.90, 95% CI 0.23-3.63); certainty not graded.

• Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. 2020 All outcomes

  Case-control genetic association studies (multiple countries) · Overall
  OR 0.90 [0.23, 3.63]
  2 studies · 1152 participants
  GRADE not reported
• Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. 2020 All outcomes

  Case-control genetic association studies (multiple countries) · Age group: Children
  OR 0.90 [0.23, 3.63]
  2 studies
  GRADE not reported

Chlorhexidine vs Nanosil (nanosilver)

• Oral hygiene care for critically ill patients to prevent ventilator‐associated pneumonia 2020 · Cochrane All outcomes
  Chlorhexidine versus Nanosil (Khaky 2018): no evidence of a difference in mortality; single study.
  1 study
  GRADE not reported

Tooth-coloured direct restorative materials (composite, compomer, giomer, RMGIC, HVGIC, open-sandwich) vs No comparator

After trim-and-fill adjustment the absence-of-recurrent-caries success rate was 0.878 (95% CI 0.828-0.915; ungraded), a negligible change.

• Success rate of proximal tooth-coloured direct restorations in primary teeth at 24 months: a meta-analysis. 2020 All outcomes

  24 months · Trim-and-fill adjusted (publication-bias sensitivity)
  Proportion 0.878 [0.828, 0.915]
  38 (30 observed + 8 imputed) studies
  GRADE not reported

TT genotype of AMELX rs946252 vs CC genotype

The pooled odds ratio was 1.03 (95% CI 0.28 to 3.75).

• Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. 2020 All outcomes

  Ethnicity: Mixed (n=1)
  OR 1.03 [0.28, 3.75]
  1 study
  GRADE not reported

Amoxicillin + metronidazole + SRP vs SRP

The review found no eligible studies for this question.

• Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes

  Long-term (≥ 1 year)
  Included studies have not reported this outcome
  Studies not reported
  No studies found

Any antimicrobial mouthwash and/or nasal spray (alone or in combination), at any concentration, delivered to healthcare workers, with or without the same intervention given to the patients with COVID-19 vs No treatment or saline or water

The review found no eligible studies for this question.

• Use of antimicrobial mouthwashes (gargling) and nasal sprays by healthcare workers to protect them when treating… 2020 · Cochrane All outcomes
  No data available (no included studies)
  0 studies
  No studies found