Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,323 questions · 5,762 findings · 263 reviews · Dental caries

No studies found 321 · 5.6%GRADE not reported 4,450 · 77.2%Very low 455 · 7.9%Low 297 · 5.2%Moderate 200 · 3.5%High 39 · 0.7%

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Metal-free single crowns (full-contour zirconia) vs Cast gold (conventional metal) single crowns

Crown failure · Adults (18 years or older) needing a single crown in the molar or premolar region

It is very uncertain whether metal-free single crowns (full-contour zirconia) changes crown failure compared with cast gold (conventional metal) single crowns (very low certainty).

2 findings from 1 review

High-viscosity glass-ionomer ART restorations vs Conventional treatment using composite (with local anaesthetic)

Restoration failure (primary dentition) · Children with carious primary teeth

ART using H-GIC led to higher restoration failure (primary teeth) compared with conventional treatment using composite (with local anaesthetic); GRADE not reported.

1 finding from 1 review

New types of fissure sealant (e.g. ormocer-based) vs No sealant (control)

Outcome not reported · Children and adolescents (general population, aged under 20 years)

The review found no eligible studies for this question.

1 finding from 1 review

High-viscosity glass-ionomer ART restorations vs Conventional treatment using H-GIC (rotary instruments)

Pain (during procedure, primary dentition) · People with dental caries in primary teeth (mainly children)

ART using high-viscosity glass ionomer cement (H-GIC), hand… showed no clear difference in pain (during procedure, primary dentition) compared with conventional treatment using H-GIC (rotary instruments) (low certainty).

1 finding from 1 review

Fluoride supplementation (tablets, drops, lozenges or chewing gum) vs placebo or no treatment

Filled primary surfaces at 3 years · Pregnant women (for preventing dental caries in the primary teeth of their children)

Fluoride supplementation (tablets, drops, lozenges or chewing gum) showed no clear difference in filled primary surfaces at 5 years compared with placebo or no treatment; GRADE not reported.

2 findings from 1 review

Metal-free cantilevered FDPs (feldspathic-veneered zirconia) vs Metal-ceramic cantilevered FDPs

Cantilevered bridge failure · Adults (18 years or older) needing replacement of one premolar or incisor with a cantilevered fixed dental prosthesis
1 finding from 1 review

Fluoride supplementation (tablets, drops, lozenges or chewing gum) vs placebo or no treatment

Caries presence in primary teeth · Pregnant women (for preventing dental caries in the primary teeth of their children)

It is very uncertain whether fluoride supplementation (tablets, drops, lozenges or chewing gum) changes children with caries in the primary teeth at 3 years compared with placebo or no treatment (very low certainty).

2 findings from 1 review

Metal-free cantilevered FDPs (feldspathic-veneered zirconia) vs Metal-ceramic cantilevered FDPs

Gingival index (GI) · Adults (18 years or older) needing replacement of one premolar or incisor with a cantilevered fixed dental prosthesis

Metal-free cantilevered FDPs (feldspathic-veneered zirconia) showed no clear difference in gingival index (GI) compared with metal-ceramic cantilevered FDPs; GRADE not reported.

1 finding from 1 review

Fluoride supplementation (tablets, drops, lozenges or chewing gum) vs placebo or no treatment

Fluorosis (maxillary teeth) at 5 years · Pregnant women (for preventing dental caries in the primary teeth of their children)

It is very uncertain whether fluoride supplementation (tablets, drops, lozenges or chewing gum) changes fluorosis (maxillary teeth) at 5 years compared with placebo or no treatment (very low certainty).

1 finding from 1 review

High-viscosity glass-ionomer ART restorations vs Conventional treatment using composite (with local anaesthetic)

Pain (primary dentition) · Children with carious primary teeth

ART using H-GIC showed no clear difference in pain (primary dentition) compared with conventional treatment using composite (with local anaesthetic); GRADE not reported.

1 finding from 1 review

Fluoride supplementation (tablets, drops, lozenges or chewing gum) vs placebo or no treatment

Caries in primary teeth: dmft (3 years) · Pregnant women (for preventing dental caries in the primary teeth of their children)

The review found no eligible studies for this question.

1 finding from 1 review

Metal-free implant-supported single crowns (zirconia veneered with feldspathic ceramic) vs Metal-ceramic implant-supported single crowns

Marginal bone level (first bone to implant contact, FBIC) · Adults (18 years or older) with one missing tooth in the aesthetic zone needing an implant-supported single crown

Metal-free implant-supported single crowns (zirconia veneered with… showed no clear difference in marginal bone level (first bone to implant contact, FBIC) compared with metal-ceramic implant-supported single crowns; GRADE not reported.

4 findings from 1 review
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ART using glass ionomer cement (GIC) vs Amalgam restoration

Restoration failure (primary dentition) · Children and adolescents with dental caries (primary teeth and permanent immature teeth)

ART using glass ionomer cement (GIC) showed no clear difference in restoration failure (primary teeth) compared with conventional treatment using amalgam; GRADE not reported.

1 finding from 1 review

Dementia (any type or severity) vs Older people without dementia

Retained roots (mean number) · Older people (aged 60 years or older) with dementia

Retained roots were more common in older people with dementia (0.2 to 10) than without (0.0 to 1.2); no meta-analysis was performed (ungraded).

1 finding from 1 review

Resin-based fissure sealant (2nd/3rd/4th generation) vs No sealant (control/no treatment)

Caries on occlusal surfaces of permanent molars (12 months) · Children and adolescents (general population, aged under 20 years)

Resin-based fissure sealant (2nd/3rd/4th generation) led to lower caries on occlusal surfaces of permanent molars (36 months) compared with no sealant (control/no treatment); GRADE not reported.

3 findings from 1 review

Metal-free tooth-supported FDPs (pressed veneering ceramic) vs Metal-free tooth-supported FDPs (layered veneering ceramic)

Aesthetics · Adults (18 years or older) needing a three-unit tooth-supported fixed dental prosthesis
1 finding from 1 review
  • No comparative data were presented with regard to aesthetics. Aesthetics evaluated by the patient was reported dichotomously (yes/no) in the trial but no between-group estimate was presented.
    1 study
    GRADE not reported