Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,556 questions · 10,375 findings · 429 reviews · All outcomes

No studies found 1,344 · 13%GRADE not reported 6,832 · 65.9%Very low 1,228 · 11.8%Low 613 · 5.9%Moderate 290 · 2.8%High 68 · 0.7%

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Clinical examination with risk-based recall vs Clinical examination with 6-month recall

Periodontal disease: gingival bleeding (percentage of sites) · Dentate adults (aged 18 years and older) receiving dental check-ups in UK general dental practices (regular attenders)

Clinical examination with risk-based recall showed no clear difference in periodontal disease: gingival bleeding (percentage of sites) compared with clinical examination with 6-month recall (high certainty).

1 finding from 1 review

Electrical counter-stimulation device (DentalVibe) vs Conventional treatment (no stimulation)

Acceptance of LA · Children and adolescents having dental treatment under local anaesthetic without general anaesthesia

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Dental caries in permanent teeth · Children (permanent dentition) worldwide

In Africa, the pooled prevalence of permanent-teeth caries in children was 58.9% (95% CI 29.4 to 83.1); certainty not graded.

1 finding from 1 review

Video modelling acclimatisation for LA vs Oral hygiene video

Completion of dental treatment · Children and adolescents having dental treatment under local anaesthetic without general anaesthesia

The review found no eligible studies for this question.

1 finding from 1 review

Spectra caries detection device (Air Techniques; blue fluorescence) vs Reference standard (histology, excavation, or enhanced visual examination)

Diagnostic accuracy (sensitivity and specificity) for detection of early enamel caries (D1 threshold) · Asymptomatic children, adolescents, or adults presenting for clinical examination (in vivo studies), or extracted teeth of children or…
1 finding from 1 review
  • Fluorescence devices for the detection of dental caries 2020 · Cochrane All outcomes
    Up to 3 months between index test and reference standard (in vivo studies)
    The Spectra caries detection device fits into the blue fluorescence category but no studies provided data for inclusion in the meta-analysis (Markowitz 2015).
    1 study
    GRADE not reported

rs1126478, co-dominant model (GA genotype) vs GG or AA genotype

Dental caries · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

rs1126478 showed no significant association with dental caries under a co-dominant model (OR 0.97, 95% CI 0.72 to 1.32; ungraded).

1 finding from 1 review

Audiovisual distraction vs Conventional treatment

Successful LA/painless treatment · Children and adolescents having dental treatment under local anaesthetic without general anaesthesia

The review found no eligible studies for this question.

1 finding from 1 review

Intralesional betamethasone vs intralesional injections of triamcinolone acetonide

Clinical resolution · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment

Intralesional betamethasone may leads to higher clinical resolution compared with intralesional triamcinolone acetonide (low certainty).

1 finding from 1 review

Intervention not reported

Prevalence of GERD/reflux (esophagitis or positive pH testing) · Adults with dental erosion

Among patients with dental erosion, 64% to 75% had GERD or reflux findings across four studies; evidence is ungraded and not pooled.

1 finding from 1 review

Clindamycin + SRP vs Doxycycline + SRP

Probing pocket depth · Adults with aggressive periodontitis

It is very uncertain whether clindamycin + SRP changes probing pocket depth compared with doxycycline + SRP (very low certainty).

2 findings from 1 review

Toothbrushing (with or without antiseptics), as part of oral hygiene care vs No toothbrushing (with or without antiseptics)

Caregivers' preferences for oral hygiene care · Critically ill adults receiving mechanical ventilation in ICU

The review found no eligible studies for this question.

1 finding from 1 review