Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,556 questions · 10,375 findings · 429 reviews · All outcomes

No studies found 1,344 · 13%GRADE not reported 6,832 · 65.9%Very low 1,228 · 11.8%Low 613 · 5.9%Moderate 290 · 2.8%High 68 · 0.7%

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Any antimicrobial mouthwash and/or nasal spray (alone or in combination), at any concentration, delivered to the patient or HCW before and/or after an AGP vs No treatment or saline or water

Other adverse events (allergy, irritation/burning of nasal, oral or oropharyngeal mucosa, long-term staining of mucous membranes or teeth, accidental ingestion) · Patients without suspected or confirmed COVID-19 infection undergoing aerosol-generating procedures (AGPs), and the healthcare workers…

The review found no eligible studies for this question.

1 finding from 1 review

General ventilation (e.g. natural ventilation, exhaust fans, opening windows) vs No general ventilation / standard operatory

Outcome not reported · Dental healthcare providers (dentist, dental surgery assistant, dental hygienist, dental technologist, dental laboratory staff, dental…

The review found no eligible studies for this question.

1 finding from 1 review

G allele of ENAM rs3796704 vs A allele of ENAM rs3796704

Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

No significant association between G allele vs A allele of ENAM rs3796704 and dental caries susceptibility (G vs A model: OR 1.11, 95% CI 0.57-2.15) in the Ethnicity: Mixed subgroup; certainty not graded.

4 findings from 1 review
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Resin-based fissure sealant vs Fluoride varnish

Time taken to apply pit and fissure sealant or fluoride varnish · Children and adolescents (general population, aged under 20 years)

The review found no eligible studies for this question.

1 finding from 1 review

G allele of ENAM rs1264848 vs A allele of ENAM rs1264848

Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

No significant association between G allele vs A allele of ENAM rs1264848 and dental caries susceptibility (G vs A model: OR 0.93, 95% CI 0.65-1.32); certainty not graded.

2 findings from 1 review

AG genotype of ENAM rs3796704 vs AA genotype of ENAM rs3796704

Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

No significant association between AG genotype vs AA genotype of ENAM rs3796704 and dental caries susceptibility (AG vs AA model: OR 0.35, 95% CI 0.07-1.74) in the Age group: Children subgroup; certainty not graded.

4 findings from 1 review
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CT + TT genotype (T-allele carriers) of AMELX rs17878486 vs CC genotype of AMELX rs17878486

Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

The CT + TT genotype (T-allele carriers) of AMELX rs17878486 was associated with increased dental caries risk (CT + TT vs CC model: OR 5.72, 95% CI 2.83-11.59) after excluding the outlier study (Ergoz 2014); certainty not graded.

7 findings from 1 review
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Amoxicillin + metronidazole + SRP vs SRP

Probing pocket depth · Adults with periodontitis (chronic and aggressive)

Amoxicillin + metronidazole + SRP led to lower probing pocket depth compared with SRP; GRADE not reported.

3 findings from 1 review

AG genotype of LTF rs1126478 vs AA genotype of LTF rs1126478

Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

No significant association between AG genotype vs AA genotype of LTF rs1126478 and dental caries susceptibility (AG vs AA model: OR 1.07, 95% CI 0.80-1.43) in the Ethnicity: Asian subgroup; certainty not graded.

3 findings from 1 review

Topical clobetasol propionate vs Topical ciclosporin

Pain resolution · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment

It is very uncertain whether topical clobetasol propionate changes pain resolution compared with topical ciclosporin (very low certainty).

1 finding from 1 review

Azithromycin + SRP vs SRP

Percentage of bleeding on probing (BOP) · Adults with periodontitis (chronic and aggressive)

Azithromycin + SRP led to lower percentage of bleeding on probing (BOP) compared with SRP; GRADE not reported.

2 findings from 1 review

Hypnosis vs Conventional treatment

Physical/verbal resistance and self-reported pain during LA (other studies) · Children and adolescents having dental treatment under local anaesthetic without general anaesthesia

Hypnosis led to lower physical/verbal resistance and self-reported pain during LA (other… compared with conventional treatment; GRADE not reported.

1 finding from 1 review

CT + TT genotype (T-allele carriers) of AMELX rs6639060 vs CC genotype of AMELX rs6639060

Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

No significant association between CT + TT genotype (T-allele carriers) vs CC genotype of AMELX rs6639060 and dental caries susceptibility (CT + TT vs CC model: OR 1.14, 95% CI 0.56-2.29) in the Ethnicity: Caucasian subgroup; certainty not graded.

3 findings from 1 review