Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,860 questions · 64,864 findings · 4,913 reviews · Headline outcomes only

No studies found 13,869 · 21.4%GRADE not reported 3,491 · 5.4%Very low 16,300 · 25.1%Low 17,338 · 26.7%Moderate 10,900 · 16.8%High 2,966 · 4.6%

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Corticosteroids vs placebo

Withdrawals due to adverse events · inactive EoE patients

Corticosteroids may leads to lower withdrawals due to adverse events 12 to 50 weeks compared with placebo (low certainty).

1 finding from 1 review

Biologics vs placebo

Clinical improvement (dichotomous) · active EoE patients

Biologics showed no clear difference in clinical improvement (dichotomous) compared with placebo (low certainty).

1 finding from 1 review

Biologics vs placebo

Histological improvement (dichotomous) · active EoE patients

Biologics probably leads to higher histological improvement (dichotomous) compared with placebo (moderate certainty).

1 finding from 1 review

Biologics vs placebo

Withdrawals due to adverse events · active EoE patients

Biologics showed no clear difference in withdrawals due to adverse events 12 to 44 weeks compared with placebo (low certainty).

1 finding from 1 review

Cromolyn sodium vs placebo

Withdrawals due to adverse events · active EoE pediatric patients

Cromolyn sodium showed no clear difference in withdrawals due to adverse events at 8 weeks compared with placebo (low certainty).

1 finding from 1 review

Corticosteroids vs placebo

Histological improvement (dichotomous) · active EoE patients

Corticosteroids leads to higher histological improvement (dichotomous) compared with placebo (high certainty).

1 finding from 1 review