Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

592 questions · 793 findings · 32 reviews · Periodontology

No studies found 148 · 18.7%GRADE not reported 429 · 54.1%Very low 137 · 17.3%Low 53 · 6.7%Moderate 14 · 1.8%High 12 · 1.5%

Moxifloxacin + SRP vs SRP

Clinical attachment level (CAL) · Adults with chronic periodontitis

Moxifloxacin + SRP led to lower clinical attachment level (CAL) compared with SRP; GRADE not reported.

2 findings from 1 review

Clarithromycin + SRP vs SRP

Probing pocket depth · Adults with periodontitis (chronic and aggressive)

Clarithromycin + SRP led to lower probing pocket depth compared with SRP; GRADE not reported.

2 findings from 1 review

Doxycycline + SRP vs SRP

Percentage of bleeding on probing (BOP) · Adults with aggressive periodontitis

Doxycycline + SRP showed no clear difference in percentage of bleeding on probing (BOP) compared with SRP; GRADE not reported.

3 findings from 1 review

Amoxicillin + metronidazole + SRP vs Clarithromycin + SRP

Percentage of bleeding on probing (BOP) · Adults with aggressive periodontitis

Amoxicillin + metronidazole + SRP showed no clear difference in percentage of bleeding on probing (BOP) compared with clarithromycin + SRP; GRADE not reported.

2 findings from 1 review

Amoxicillin + clavulanate + SRP vs Tetracycline + SRP

Percentage of bleeding on probing (BOP) · Adults with aggressive periodontitis

Amoxicillin + clavulanate + SRP showed no clear difference in percentage of bleeding on probing (BOP) compared with tetracycline + SRP; GRADE not reported.

1 finding from 1 review

Metronidazole + SRP vs SRP

Adverse events · Adults with periodontitis (chronic and aggressive)

It is very uncertain whether metronidazole + SRP changes adverse events compared with SRP (very low certainty).

1 finding from 1 review